
ブロモクリプチン
化学名:ブロモクリプチン
CAS番号.25614-03-3
英語名:Bromocriptine
CBNumberCB6136426
MFC32H40BrN5O5
MW654.59
MOL File25614-03-3.mol
别名
ブロモエルゴクリプチン
2-ブロモ-α-エルゴクリプチン
2-ブロモ-12'-ヒドロキシ-2'-イソプロピル-5'α-(2-メチルプロピル)エルゴタマン-3',6',18-トリオン
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ブロモクリプチン物理性質
融点 | 215-218° (dec) |
比旋光度 | D20 -195° (c = 1 in methylene chloride) |
沸点 | 891.3±65.0 °C(Predicted) |
比重(密度) | 1.2734 (rough estimate) |
屈折率 | 1.6400 (estimate) |
酸解離定数(Pka) | pKa 4.90±0.05(80% MCS t = RT) (Uncertain) |
水溶解度 | 2.07mg/L(温度表記なし) |
CAS データベース | 25614-03-3(CAS DataBase Reference) |
毒性 | An ergot alkaloid derivative that exhibits potent dopamine agonist properties, particularly at D2 dopamine receptors. Bromocriptine, like dopamine, inhibits prolactin release from the pituitary and so is used in endocrine disorders, such as hyperprolactinemia. It is also used in the treatment of Parkinson’s disease. A large “first-pass” effect is seen with bromocriptine, and peak concentrations occur about 1.5-3 h after ingestion, with a half-life of about 3 h. Nausea, vomiting, and orthostatic hypotension are among the acute adverse effects. Long-term use has been associated with dyskinesias, constipation, psychoses, digital spasm, and erythromelalgia. The LD50 in rabbits exceeds 1 g/kg, p.o., and 12 mg/kg, i.v. |