ホウ酸

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Danger

• 注意書き

  P201：使用前に取扱説明書を入手すること。

  P202：全ての安全注意を読み理解するまで取り扱わないこ と。

  P280：保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。

  P308+P313：暴露または暴露の懸念がある場合：医師の診断/手当てを 受けること。

  P405：施錠して保管すること。

  P501：内容物/容器を．．．に廃棄すること。

ホウ酸 価格

MSDS Information

• Orthoboric acid

ホウ酸 化学特性,用途語,生産方法

• 外観

  無色澄明の液体

• 溶解性

  水及びエタノールにやや溶けやすい。

• 用途

  調製液製造原料、無機合成(ほう酸塩製造)原料、ガラス原料、写真薬、殺虫剤。

• 用途

  殺生物剤、セラミック、ゴム、難燃剤

• 用途

  硝子、顔料

• 用途

  緩衝液調製用(アミノ酸分析、蛍光分析）。

• 用途

  汎用試薬、調製液製造原料。

• 用途

  ガラス?ホウロウ原料、医薬、ニッケルメッキ添加剤、防火剤、防腐剤、写真薬

• 効能

  眼科用消毒薬

• 特徴

  平面三角形のBO3が水素結合で二次元網面を形成．B－O 136 pm，O－H 97 pm，O－H…O 272 pm

  

• 商品名

  ホウ酸 (中北薬品); ホウ酸 (丸石製薬); ホウ酸 (健栄製薬); ホウ酸 (司生堂製薬); ホウ酸 (吉田製薬); ホウ酸 (山善製薬); ホウ酸 (恵美須薬品化工); ホウ酸 (日医工); ホウ酸 (日医工); ホウ酸 (日興製薬); ホウ酸 (東海製薬)

• 化学的特性

  White powder or granules and odorless. It is incompatible with potassium, acetic anhydride, alkalis, carbonates, and hydroxides. Boric acid has uses in the production of textile fiberglass, flat panel displays, and eye drops. Boric acid is recognized for its application as a pH buffer and as a moderate antiseptic agent and emulsifier.

• 物理的性質

  Colorless, transparent triclinic crystal or white granule or powder; density 1.435 g/cm³; melts at 171°C under normal heating; however, slow heating causes loss of water; sparingly soluble in cold water (4.7% at 20°C); pH of 0.1M solution 5.1; readily dissolves in hot water (19.1% at 80°C and 27.5% at 100°C); also soluble in lower alcohols and moderately soluble in pyridine.

• 使用

  For weatherproofing wood and fireproofing fabrics; as a preservative; manufacture of cements, crockery, porcelain, enamels, glass, borates, leather, carpets, hats, soaps, artificial gems; in nickeling baths; cosmetics; printing and dyeing, painting; photography; for impregnating wicks; electric condensers; hardening steel. Also used as insecticide for cockroaches and black carpet beetles.

• 調製方法

  Boric acid occurs naturally as the mineral sassolite. However, the majority of boric acid is produced by reacting inorganic borates with sulfuric acid in an aqueous medium. Sodium borate and partially refined calcium borate (colemanite) are the principal raw materials. When boric acid is made from colemanite, the fineground ore is vigorously stirred with mother liquor and sulfuric acid at about 908℃. The by-product calcium sulfate is removed by filtration, and the boric acid is crystallized by cooling the filtrate.

• 製造方法

  Boric acid is produced from borax, colemanite, or other inorganic borates by reaction with sulfuric acid or hydrochloric acid, and cooling the solution to proper temperature:
  Na₂B₄O₇ ? 10Η₂Ο + H₂SO₄ → 4H₃BO₃ + Na₂SO₄ + 5H₂O
  It also may be prepared by extraction of weak borax brine with a kerosene solution of an aromatic diol, such as 2-ethyl-1,3-hexanediol or 3-chloro- 2-hydroxy-5-(1,1,3,3-tetramethylbutyl)benzyl alcohol. The diol-borate chelate formed separates into a kerosene phase. Treatment with sulfuric acid yields boric acid which partitions into aqueous phase and is purified by recrystallization.

• 世界保健機関（WHO）

  Boric acid and some borates were formerly extensively used as disinfectants and antiinflammatory agents. By the late 1960s an association between the death of many infants and application of high concentrations of boric acid contained in topical preparations used in the treatment of napkin rash had been established. This led to the restriction of the use of boric acid in pharmaceutical preparations by many regulatory authorities. In some countries it is now permitted only as an ingredient in ophthalmological preparations.

• 一般的な説明

  Boric acid is a weak monobasic acid, it accepts OH^- ions, hence is a Lewis acid. In boric acid, B is sp² hybridized, forming a planar triangle structure. The principal oxide of boron, B₂O₃, is obtained as a vitreous solid by dehydration of boric acid at red heat.

• 危険性

  Toxic via ingestion. Use only weak solu- tions. Irritant to skin in dry form.

• 応用例（製薬）

  Boric acid is used as an antimicrobial preservative in eye drops, cosmetic products, ointments, and topical creams. It is also used as an antimicrobial preservative in foods.
  Boric acid and borate have good buffering capacity and are used to control pH; they have been used for this purpose in external preparations such as eye drops.
  Boric acid has also been used therapeutically in the form of suppositories to treat yeast infections. In dilute concentrations it is used as a mild antiseptic, with weak bacteriostatic and fungistatic properties, although it has generally been superseded by more effective and less toxic disinfectants.

• 職業ばく露

  Boric acid is a fireproofing agent for wood; a preservative, and an antiseptic. It is used in the manufacture of glass, pottery, enamels, glazes, cosmetics, cements, porcelain, borates, leather, carpets, hats, soaps; artificial gems; in tanning leather; printing, dyeing, painting, and photography.

• 貯蔵

  Boric acid is hygroscopic and should therefore be stored in an airtight, sealed container. The container must be labeled ‘Not for Internal Use’.

• 輸送方法

  UN 3077 Environmentally hazardous substances, solid, n.o.s., Hazard class: 9; Labels: 9—Miscellaneous hazardous material, Technical Name Required.

• 純化方法

  Crystallise the acid three times from H2O (3mL/g) between 100o and 0o, after filtering through sintered glass.Dry it to constant weight over metaboric acid in a desiccator. It is steam volatile. After two recrystallisations of ACS grade. it had Ag at 0.2 ppm. Its solubility (%) in H2O is 2.66 at 0o, 4.0 at 12o and 24 at 80o. At 100o it loses H2O to form metaboric acid (HBO2). When it is heated to redness or slowly to 200o, or over P2O5 in vacuo, it dehydrates to boric anhydride (B2O3) [1303-82-6] to give a white hard glass or crystals with m ~294o.The glass softens on heating and liquefies at red heat. It is an astringent, a fungicide and an antibacterial. [McCulloch J Am Chem Soc 59 2650 1937, Kelly J Am Chem Soc 63 1137 1941, Taylor & Cole J Chem Soc 70 1926, Conti J Soc Chem Ind 44 343T 1925.]

• 不和合性

  Boric acid decomposes in heat above 100 C, forming boric anhydride and water. Boric acid is hygroscopic; it will absorb moisture from the air. Boric acid aqueous solution is a weak acid; incompatible with strong reducing agents including alkali metals and metal hydrides (may generate explosive hydrogen gas); acetic anhydride, alkali carbonates, and hydroxides. Violent reaction with powdered potassium metal, especially if impacted. Attacks iron in the presence of moisture.

• 廃棄物の処理

  Boric acids may be recovered from organic process wastes as an alternative to disposal.

• 規制状況(Regulatory Status)

  Accepted for use as a food additive in Europe. Included in the FDA Inactive Ingredients Database (IV injections; ophthalmic preparations; (auricular) otic solutions; topical preparations). Reported in the EPA TSCA Inventory. In the UK, the use of boric acid in cosmetics and toiletries is restricted. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

• 参考文献

  W.H. Zachariasen, Acta Crystallogr., 7, 305 (1954), DOI: 10.1107/S0365110X54000886.

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