SUBSTANCE P
化学名:SUBSTANCE P
CAS番号.12769-48-1
英語名:SUBSTANCE P
CBNumberCB6114259
MFC63H98N18O13S
MW1347.63
MOL File12769-48-1.mol
SUBSTANCE P 化学特性,用途語,生産方法
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作用機序
Substance P is an 11-amino-acid neuropeptide belonging to the tachykinin family, mediating its biological actions through activation of G protein–coupled tachykinin (neurokinin-1 [NK1]) receptors. Its proposed physiological roles include inflammation, pain, GI and respiratory function, stress responses, and emesis. Substance P is uniquely associated with the monoamine neurotransmitters, 5-HT and NE. -
臨床応用
The 5-HT neurons coexpress substance P, and the firing of NE neurons is modulated by substance P. Preclinical studies have supported a role of the substance P–NK1 receptor system in stress-related disorders, which has guided the antidepressant development of centrally active NK1 receptor antagonists, such as aprepitant. The NK1 antagonists are generally well tolerated and exhibit less nausea and sexual dysfunction than some currently used antidepressants.
SUBSTANCE P 生産企業
Global(35)Suppliers
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Zhejiang J&C Biological Technology Co.,Limited
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Shanghai Hanhong Scientific Co.,Ltd.
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