2'-ヒドロキシプロピオフェノン

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Warning

• 危険有害性情報

  H315：皮膚刺激

  H319：強い眼刺激

  H335：呼吸器への刺激のおそれ

• 注意書き

  P261：粉じん/煙/ガス/ミスト/蒸気/スプレーの吸入を避ける こと。

  P264：取扱い後は皮膚をよく洗うこと。

  P264：取扱い後は手や顔をよく洗うこと。

  P271：屋外または換気の良い場所でのみ使用すること。

  P280：保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。

  P302+P352：皮膚に付着した場合：多量の水と石鹸で洗うこと。

  P305+P351+P338：眼に入った場合：水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。

2'-ヒドロキシプロピオフェノン 価格

MSDS Information

• 2'-Hydroxypropiophenone

2'-ヒドロキシプロピオフェノン 化学特性,用途語,生産方法

• 外観

  無色～黄褐色、液体

• 化学的特性

  CLEAR BROWNISH LIQUID

• 製造方法

  Obtained by Fries rearrangement of phenyl propionate
  with aluminium chloride in refluxing carbon disulfide ?, then at 130–150° for 2–3 h after solvent elimination (32–35%)
  with aluminium chloride in chlorobenzene using microwave irradiation for 3 ? min at 106° (28%)
  with aluminium chloride in nitrobenzene at 50° for 18 h (16%) or at ? 20° for 48 h (10%)
  with aluminium chloride in nitromethane at 20° for 7 days (20%)
  with aluminium chloride in heptane at 80–90° for 7 h (53%) or in tetrachlo-? roethane at 95° for 5 h (43%)
  with aluminium chloride without solvent at 250° for 5 min or at 180–200° for ? 15 min (76–78%), at 140–160° (32–35%), at 140°
  with zirconium chloride in o-dichlorobenzene at 120° for 3 h (83%)
  with titanium tetrachloride in o-dichlorobenzene at 150° for 1 h (62%) ?, in nitromethane at 20° for 7 days (13%) or without solvent at 50° for 10 h (30%)
  with titanium tetrabromide in o-dichlorobenzene at 150° for 1 h (60%)
  with stannic chloride at 50° for 3 h (25%)
  with boron trifluoride at 120–135° for 15 min (15%)
  with zinc chloride at 180–200° for 15 min (10%)
  with polyphosphoric acid at 100° (13%)
  Also obtained by Friedel–Crafts acylation of phenol with propionyl chloride in the presence of aluminium chloride (40%), at 120–130° for 1 h (45%) according to the method
  Also obtained by acylation of phenol with propionic acid
  in the presence of boron trifluoride at 165° for 1 h (45%) or at 80° for ? 2 h (8%)
  in the presence of polyphosphoric acid at 100° for 10 min (by-product)
  in the presence of zinc chloride at 160° for 1 h
  Also obtained by isomerization of 4-hydroxypropiophenone with aluminium chloride (1.5 equiv) at 165° for 1 h (40%) or at 180–200° for 15 min (55%)
  Also obtained by demethylation of 2-propionylanisole with fuming hydrochloric acid (d = 1.19) in a sealed tube at 110° for 6 h
  Also obtained (by-product) by heating 3-tert-butyl-4-hydroxypropiophenone with aluminium chloride at 170° for 15 min (13%)
  Also obtained by treatment of 2,3-dimethylchromone with sodium ethoxide in boiling ethanol for 30 h according to the method
  Also obtained from 2-allylphenol by treatment with perbenzoic acid in ethyl ether, first at 0°, then between 0° and 25° for 24 h (78%)
  Also obtained by reaction of 2-bromophenyl propionate in a ethyl ether/hexane/THF mixture at low temperature (?78 to ?95°) with sec-butyllithium to give, after hydrolysis, the titled ketone (metal-promoted Fries rearrangement) (17%)
  Also obtained by reaction of ethylmagnesium bromide
  with 2-hydroxybenzamide in boiling benzene, followed by hydrolysis ? (30%)
  with 2-hydroxy-N,N-diethylbenzamide in boiling benzene, followed by ? hydrolysis (82–84%)
  Also isolated by heating of 1-(o-hydroxyphenyl)cyclopropyltrimethylam-monium iodide for 1 h at 140° with 1.5 equiv of N,N-diisopropylethylamine (not water-free) (38%)
  Also obtained by hydrolysis of 2-(1-methyliminopropyl)phenol (4aa) with aqueous acetic acid/THF at 40° for 4 h (86%)
  Also obtained by photolysis of phenyl propionate in water or in solution containing b-cyclodextrine (254 nm) at 25° for 2 h
  Also obtained by treatment of 2-(1-hydroxypropyl)phenol with MnO2 in methylene chloride for 7 h at r.t.

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2'-ヒドロキシプロピオフェノン スペクトルデータ(¹HNMR、¹³CNMR、ESR、IR1、MS、Raman)

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