塩化リゾチーム

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Danger

• 危険有害性情報

  H334：吸入するとアレルギー、喘息または、呼吸困難 を起こすおそれ

• 注意書き

  P261：粉じん/煙/ガス/ミスト/蒸気/スプレーの吸入を避ける こと。

  P284：呼吸用保護具を着用すること。

  P501：内容物/容器を．．．に廃棄すること。

塩化リゾチーム 価格

MSDS Information

• Lysozyme

塩化リゾチーム 化学特性,用途語,生産方法

• 外観

  白色～わずかにうすい黄色、粉末又は顆粒

• 定義

  本品は、卵白(*)から得られる塩基性ポリペプチドである。参照表示名称：卵白

• 溶解性

  水に溶けやすく、エタノール及びアセトンに難溶である。

• 解説

  細胞膜中のN-アセチルグルコサミンとN-アセチルムラミン酸間のβ(1→4)結合を加水分解する酵素．基質特異性および分子量から四つのグループに分けられる．ニワトリの卵白から得られた卵白リゾチームが名高い．

• 用途

  プロトプラストの調製、溶菌。

• 用途

  多糖類分解酵素です。ムコ多 糖を分解します。

• 用途

  多糖類分解酵素です。ムコ多 糖を分解します。

• 化粧品の成分用途

  皮膚コンディショニング剤

• 使用上の注意

  安定性5℃で数年安定,溶液(pH 4～5)は冷蔵で数週間安定

• 説明

  Lysozyme is an antibacterial enzyme naturally present in animals and humans as a component of the innate immune system to fight against microorganisms. It belongs to a group of enzymes that are known as glycoside hydrolases. It is found in animal tissues, organs, serum as well as in tears, nasal secretions, cervical mucus, and the white of avian eggs. Lysozyme breaks the carbonhydrate chains of the bacterial skin, destroying the structural integrity of the cell wall. Thereby, it has antibacterial properties and was one of the first antibiotics studied by Sir Fleming, the discover of penicillin.
  
  Lysozyme is used either alone or in combination with other synergic compounds as an excellent preservative against many food spoiling microorganisms for fruits & vegetables, tofu & bean curd, seafood & meats, wines & sakes. Organic wines use it to reduce sulfites. It is used in non-pasteurized beer. It has been added to baby formula (to aid digestibility) and gastrointestinal treatments for the elderly.  Lysozyme is used in skin care, to cure and prevent acne and bed sores, as well as in optical, dental, and oral conditions.

• 化学的特性

  Lysozyme (muramidase) hydrolyzes preferentially the beta-1,4 glucosidic linkages between N-acetylmuramic acid and N-acetylglucosamine which occur in the mucopeptide cell wall structure of certain microorganisms, such as Micrococcus lysodeikticus. A somewhat more limited activity is exhibited towards chitin oligomers. Lysozyme is of widespread distribution in animals and plants. That which has been most extensively studied is from hen egg white (lysozyme C). Lysozyme is also found in mammalian secretions and tissues, saliva, tears, milk, cervical mucus, leukocytes, kidneys, etc. Lysozyme is inhibited by surface-active reagents such as dodecyl sulfate, alcohols and fatty acids. Imidazole and indole derivatives are inhibitors via formation of change-transfer complexes. Useful for the rapid isolation of RNA from gram negative bacteria. Can be used to prepare small amounts of plasmid DNA.
  

• 使用

  Lysozyme is used to monitor transcription via real-time PCR and in sample preparation. It catalyzes the hydrolysis of peptidoglycans in bacterial cell walls and is utilized in the production of spheroplasts. Additionally, it serves as a preservative against many food-spoiling microorganisms and is applied in skincare to treat and prevent acne and bed sores, as well as in dental and oral care. Lysozyme is also used to lyse E. coli and Streptomycetes for extraction purposes, such as isolating group-specific antigens. Furthermore, it is used in non-pasteurized beer.

• 主な応用

  Lysozyme from chicken egg white has been used for the extraction of genomic DNA from bacterial cells.It has been used as an external standard for MALDI-TOF (matrix assisted laser desorption ionization-time of flight) mass analysis.
  Enzyme breaks down the cell walls of bacteria; used to prepare spheroplasts.

• 一般的な説明

  Lysozyme from chicken egg white, is a protein that can show broad spectrum of antibacterial activity against gram positive and gram negative bacteria. Its antimicrobial activity can be enhanced by pretreatment of the target microbial cells with chelating agents like ethylenediaminetetraacetic acid (EDTA).

• Biochem/physiol Actions

  Lysozyme hydrolyzes β(1→4) linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrin. Gram-positive cells are quite susceptible to this hydrolysis as their cell walls have a high proportion of peptidoglycan. Gram-negative bacteria are less susceptible due to the presence of an outer membrane and a lower proportion of peptidoglycan. However, these cells may be hydrolyzed in the presence of EDTA that chelates metal ions in the outer bacterial membrane.The enzyme is active over a broad pH range (6.0 to 9.0). At pH 6.2, maximal activity is observed over a wider range of ionic strengths (0.02 to 0.100 M) than at pH 9.2 (0.01 to 0.06 M).

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