クペロン

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Danger

• 危険有害性情報

  H301：飲み込むと有毒

  H319：強い眼刺激

  H335：呼吸器への刺激のおそれ

  H341：遺伝性疾患のおそれの疑い

  H350：発がんのおそれ

• 注意書き

  P201：使用前に取扱説明書を入手すること。

  P202：全ての安全注意を読み理解するまで取り扱わないこ と。

  P261：粉じん/煙/ガス/ミスト/蒸気/スプレーの吸入を避ける こと。

  P264：取扱い後は皮膚をよく洗うこと。

  P264：取扱い後は手や顔をよく洗うこと。

  P301+P310：飲み込んだ場合：直ちに医師に連絡すること。

  P305+P351+P338：眼に入った場合：水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。

クペロン 価格

クペロン 化学特性,用途語,生産方法

• 外観

  白色〜うすい黄褐色, 結晶〜結晶性粉末

• 溶解性

  水, エタノールにはよく溶ける。水に溶けやすく、エタノールにやや溶けにくい。

• 解説

  クペロンは白色粉末です．融点163～164 ℃．Ka 5×10－5．水，エタノールに易溶．酸性溶液から金属イオンを沈殿させる有機試薬で，バウディッシュ試薬(Baudish's reagent)とよばれている．5％ 水溶液に少量の炭酸アンモニウムを加え，密閉容器に保存して使用する．FeⅡ，FeⅢ，CuⅡ，などは完全に沈殿するので，ほかの金属から分離することができる．沈殿は強熱し，金属酸化物として定量する．金属錯塩はクロロホルムやエーテルに溶けるので，抽出により金属イオン相互の分離によく用いられる．[CAS 135-20-6]
  森北出版「化学辞典（第2版）

• 用途

  金属キレート剤, 金属の検出, 沈殿分離剤, 重合禁止剤

• 準備

  低温でフェニルヒドロキシルアミンに塩酸の存在下，亜硝酸ナトリウムを作用させ，濾過後エーテル中でアンモニアと作用させるか，エーテル中で亜硝酸アミルとアンモニアを加えて合成クペロン．

  

• 使用上の注意

  冷暗所に保存。変化しやすく長期保存は困難。毒性もあるので、取り扱いには注意する。クペロンは着色しやすく，長期保存に耐えない。また，分解性をもつことから，アンモニア雰囲気中で保存する。

• 化学的特性

  Cupferron is a creamy-white crystalline compound

• 使用

  The reagent used to be considered as specific for iron(II) and copper(II). However, in the course of later analytical studies it turned out that cupferron forms complexes with several other metals too, even in acidic medium. It is used today primarily for the determination of copper(II), but it has proved suitable for the determination of aluminium(III), bismuth(III), iron(III), mercury(II), thorium(IV), tin(IV), titanium(III), vanadium(IV) and zirconium(IV) as well. Of these, the zirconium(IV) complex is the most stable. Cupferron precipitates zirconium(IV) quantitatively from aqueous media containing sulfuric acid.
  The reagent gives a precipitate with most of the above metal ions even in strong mineral acidic medium. Only the aluminium(III) complex does not precipitate in the presence of mineral acids.
  By means of cupferron many metal ions can be separated: thus, for instance, iron(III) can be separated from aluminium(III) and manganese(II) and titanium (IV), zirconium(IV) and hafnium(IV) from many other metal ions, etc. Though the reagent makes possible several separations, the precipitates are not exactly of stoichiometric composition (they almost always contain some excess of the ligand). Hence instead of being directly weighed, the precipitates are usually ignited and the metal oxide residues weighed.

• 一般的な説明

  Light yellow or cream-colored crystals or a brown crystalline solid. As a reagent in the separation of copper and iron.

• 空気と水の反応

  Hygroscopic. Soluble in water.

• 反応プロフィール

  Cupferron may be sensitive to prolonged exposure to air. Incompatible with strong oxidizing agents, strong acids and strong bases. Forms unstable solutions with thorium, titanium and zirconium salts.

• 火災危険

  Flash point data for Cupferron are not available; however, Cupferron is probably combustible.

• 安全性プロファイル

  Confirmed carcinogen with experimental carcinogenic and tumorigenic data. Poison by intravenous route. An eye irritant. Solutions with thorium salts are unstable explosives above 15°C. Solutions with titanium or zirconium salts are unstable explosives above 40℃. When heated to decomposition it emits very toxic NH3 and NOx. See also N-NITROSO COMPOUNDS and AMINES

• 職業ばく露

  Cupferron is used to separate tin from zinc, and copper and iron from other metals in the laboratory. Cupferron also finds application as a quantitative reagent for vanadates and titanium; and for the colorimetric determination of aluminum. The potential for exposure appears to be greatest for those engaged in analytical or research studies involving use of the chemical. Workers may also be exposed to the compound during manufacturing processes.

• 発がん性

  Cupferron is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals.

• 輸送方法

  UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.

• 純化方法

  Recrystallise it twice from EtOH after treatment with Norite and finally once with EtOH. The crystals are washed with diethyl ether and air dried, then stored in the dark over solid ammonium carbonate. A standard solution (ca 0.05M prepared in air-free H2O) is prepared daily from this material for analytical work and is essentially 100% pure. [Olsen & Elving Anal Chem 26 1747 1954.] It can also be washed with Et2O, dried and stored as stated. In a sealed, dark container it can be stored for at least 12 months without deterioration. 260nm (CHCl3). max [Marvel Org Synth Coll Vol I 177 1941, Elving & Olson J Am Chem Soc 78 4206 1956, Beilstein 16 IV 891.] Possible CARCINOGEN.

• 不和合性

  Forms unstable and possibly explosive compounds with thorium salts; titanium, zirconium.

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クペロン スペクトルデータ(¹HNMR、¹³CNMR、IR1、IR2、MS)

135-20-6, クペロン キーワード