CP-154,526

CP-154,526 化学特性,用途語,生産方法

• 用途

  選択的な CRF1 受容体非ペプチド性アンタゴニストです（Ki = 2.7 nM（CRF1），>10,000 nM （CRF2）。脳透過性があります。

• 使用

  A selective, non-peptide antagonist of corticotropin releasing factor receptors (CRF1). It blocks CRF-induced adenylate cyclase activation and attenuates activation of the HPA axis by CRF. It displayed anxiolytic-like activity in the rat elevated plus-maze test; brain penetrant.

• 生物活性

  Selective, non-peptide CRF 1 receptor antagonist (K i values are 2.7 and > 10000 nM for CRF 1 and CRF 2 receptors respectively). Blocks CRF-induced adenylate cyclase activation (K i = 3.7 nM) and attenuates activation of the HPA axis by CRF. Displays anxiolytic-like activity in the rat elevated plus-maze test; brain penetrant.

CP-154,526 生産企業

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