フィサレミン

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フィサレミン 化学特性,用途語,生産方法

• 説明

  Physalaemin is an oligopeptide that is originally derived from the skin of the South American frog Physalaemus fuscumaculatus. It belongs to the class of kinins and shares a similar chemical structure and mode of action with Substance P. It is a potent vasodilator and has hypotensive effects.

• 使用

  Physalaemin is a neuropeptide found in amphibians that has shown potential in the treatment of Sjogren's disease.?

• 概要

  カエル皮膚に存在するサブスタンスP関連ペプチド

• 参考文献

  [1] Grace CR, et al. Solution conformation of non-mammalian tachykinin physalaemin in lipid micelles by nuclear magnetic resonance. Biopolymers. 2011;96(3):252-9. DOI:10.1002/bip.21519
  [2] Kobayashi J, Hydrolytic cleavage of pyroglutamyl-peptide bond. V. selective removal of pyroglutamic acid from biologically active pyroglutamylpeptides in high concentrations of aqueous methanesulfonic acid. Chem Pharm Bull (Tokyo). 2006 Jun;54(6):827-31. DOI:10.1248/CPB.54.827
  [3] Hypotensive effect of eledoisin, physalaemin and related peptides in man DOI: 10.1007/BF00535905
  [4] Physalaemin Inhibits Thyrotropin Secretion in Rats DOI: 10.1055/s-0029-1210457
  [5] Action of Physalaemin on the Ionic Transport Across the Frog Skin: Archives of Physiology and Biochemistry: Vol 105, No DOI: 10.1055/s-0029-1210457

フィサレミン 生産企業

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2507-24-6, フィサレミン キーワード