リトドリン

リトドリン 化学特性,用途語,生産方法

• 用途

  β受容体刺激剂主要用于治疗早产

• 効能

  子宮収縮抑制薬, β2アドレナリン受容体作動薬

• 説明

  Ritodrine, 4-hydroxy-α-[1-[(4′-hydroxyphenethyl)amino]ethyl]benzylic alcohol (11.1.19), differs slightly from epinephrine, and in the given example only one hydroxyl group has been added to the aromatic ring of the phenylethylamino region of classic sympathomimetics. The second major difference between the examined series is the replacement of the traditionally terminal iso-propyl or tert-butylamine region with a p-hydroxyphenylethylamine. Finally, the third difference is the presence of a methyl group at the α-atom of the phenylethylamine region of sympathomimetics, which makes it similar to isoetharine.

• 使用

  Ritodrine is a selective β2-adrenoreceptor stimulant, predominantly of the urino-genital system. It is used as a tocolytic agent for problems associated with premature miscarriages, and only in specialized medical facilities.

• 一般的な説明

  Ritodrine is a selective β2-agonist that wasdeveloped specifically for use as a uterine relaxant. Its uterineinhibitory effects are more sustained than its effects onthe cardiovascular system, which are minimal comparedwith those caused by nonselective β-agonists. The cardiovasculareffects usually associated with its administrationare mild tachycardia and slight diastolic pressure decrease.Usually, it is administered initially by intravenous infusionto stop premature labor and subsequently it may be givenorally.

• 臨床応用

  Ritodrine is a selective β2-agonist that is used exclusively for relaxing uterine muscle and inhibiting the contractions of premature labor. Terbutaline, in addition to its use as a bronchodilator, also has been used for halting the contractions of premature labor.

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