TYR-D-ALA-GLY-PHE-D-LEU ACETATE SALT

TYR-D-ALA-GLY-PHE-D-LEU ACETATE SALT 価格

TYR-D-ALA-GLY-PHE-D-LEU ACETATE SALT 化学特性,用途語,生産方法

• 使用

  [D-Ala², D-Leu⁵]-Enkephalin or DADLE has been used for use in immunocomplex kinetic assay, to determine the activation of p70^s6k by DADLE in the cell clones D2 and DOE and in non-transfected parental Rat-1 fibroblasts and to assess the analgesic effect of WIN55,212-2 in mice.

• 一般的な説明

  [D-Ala², D-Leu⁵]-Enkephalin acetate salt, also called DADLE, is an analog of endogenous δ-opioid peptide encephalin, and is metabolically stable.

• Biochem/physiol Actions

  [D-Ala2, D-Leu5]-Enkephalin can induce hibernation in ground squirrels, during summers, when they do not normally hibernate. In multiorgan block preparation, it can prolong the survival time of organs such as, heart, lung, liver, spleen and kidney, up to 46hrs. It aids in tolerance development of myocardium to ischemia. It might have tissue protective role in central nervous system. It prevents and reverses methamphetamine (METH)-induced damage of dopaminergic terminals of brain. It prevents naltrexone-sensitive PC12 cell apoptosis in serum deprivation conditions. Thus, it might play an essential role in the survival of neurons and organs.

TYR-D-ALA-GLY-PHE-D-LEU ACETATE SALT 生産企業

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