セフォペラゾンナトリウム

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Danger

• 危険有害性情報

  H317：アレルギー性皮膚反応を起こすおそれ

  H334：吸入するとアレルギー、喘息または、呼吸困難 を起こすおそれ

• 注意書き

  P261：粉じん/煙/ガス/ミスト/蒸気/スプレーの吸入を避ける こと。

  P280：保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。

  P342+P311：呼吸に関する症状が出た場合：医師に連絡すること。

セフォペラゾンナトリウム 価格

セフォペラゾンナトリウム 化学特性,用途語,生産方法

• 外観

  白色, 結晶性粉末〜粉末

• 溶解性

  水に溶け、エタノール及びアセトンにほとんど溶けない。

• 用途

  高速液体クロマトグラフ法によるセフォペラゾンナトリウム定量用標準品。

• 効能

  抗生物質, 細胞壁合成阻害薬

• 使用上の注意

  アルゴン封入

• 説明

  Cefoperazone was synthesized by Toyama Chemicals Co. in 1978. Except for the hydroxyl group, the side chain attached to the cephem nucleus is the same as that of piperacillin. Cefoperazone shows excellent activity against gram-positive (except Staphylococcus) and gram- negative bacteria, including Pseudomonas aeruginosa. Its pharmacological characteristics are unique. Cefoperazone is excreted mainly in bile, and a concentration five to tenfold higher in bile than in serum is obtained. The transfer into cerebrospinal fluid is 10 – 30 % of the serum concentration; the half-life in serum is 2.0 – 2.6h, and the degree of binding with serum protein is as high as 86.6 %.

• 化学的特性

  Faint beige powder

• 使用

  For studying the expression, binding, and inhibition of penicillin-binding proteins.Cefoperazone sodium salt is used in the study of drug-protein binding, expression and inhibition of penicillin-binding proteins during cell wall synthesis. It is as an antibacterial and antimicrobial agent useful for prevention of postoperative infection. It is used as an inhibitor of inactivation of alfa-antitrypsin.

• 臨床応用

  Cefoperazone sodium is a third-generation, antipseudomonalcephalosporin that resembles piperacillinchemically and microbiologically. It is active against manystrains of P. aeruginosa, indole-positive Proteus spp.,Enterobacter spp., and S. marcescens that are resistant tocefamandole. It is less active than cephalothin againstGram-positive bacteria and less active than cefamandoleagainst most of the Enterobacteriaceae. Like piperacillin,cefoperazone is hydrolyzed by many of the β-lactamasesthat hydrolyze penicillins. Unlike piperacillin, however, itis resistant to some (but not all) of the β-lactamases thathydrolyze cephalosporins.Cefoperazone is excreted primarily in the bile. Hepaticdysfunction can affect its clearance from the body.

セフォペラゾンナトリウム 上流と下流の製品情報

セフォペラゾンナトリウム 生産企業

Global(401)Suppliers

62893-20-3, セフォペラゾンナトリウム キーワード