2,4,6-トリメチルアニリン

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Danger

• 危険有害性情報

  H315：皮膚刺激

  H319：強い眼刺激

  H330：吸入すると生命に危険

• 注意書き

  P260：粉じん/煙/ガス/ミスト/蒸気/スプレーを吸入しないこ と。

  P280：保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。

  P301+P312：飲み込んだ場合：気分が悪い時は医師に連絡する こと。

  P305+P351+P338：眼に入った場合：水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。

2,4,6-トリメチルアニリン 価格

MSDS Information

• 2,4,6-Trimethylbenzenamine

2,4,6-トリメチルアニリン 化学特性,用途語,生産方法

• 外観

  うすい黄色～暗赤褐色, 澄明の液体

• 溶解性

  水に難溶。有機溶媒に可溶。エタノール及びアセトンに溶け、水にほとんど溶けない。

• 用途

  染料、顔料、その他有機工業薬品中間体。

• 化学的特性

  clear yellow to brown liquid. Insoluble in water, soluble in organic solvents such as ethanol and ether.

• 使用

  2,4,6-Trimethylaniline is useful for the preparation of Grubbs' catalyst. It is used as a precursor to dyes. It undergoes condensation reaction with glyoxal to prepare glyoxal-bis(mesitylimine). It is also involved in the preparation of 1,3-diketimines ligands by condensation with 1,3-diketones. Further, it is used for the production of Acid Blue 129 dye, which is useful in histochemistry studies. In addition to this, it serves as a building block to various bulky ligands.

• 製造方法

  2,4,6-Trimethylaniline is prepared by selective mononitration of mesitylene, avoiding oxidation of the methyl groups.
  Mix sulfuric acid and nitric acid into mixed acid, nitrify with mesitylene at atmospheric pressure below 10°C for 4 hours, stand for stratification, and let off the waste acid. The obtained 2,4,6-trimethylnitrobenzene, iron powder, hydrochloric acid and water were prepared in a ratio of 1:3.74:0.9:2.22 (mol ratio) for reduction reaction at 100-105°C for 8h. Crude 2,4,6-Trimethylaniline was then distilled off from the reduced material and purified by distillation.

• 一般的な説明

  2,4,6-Trimethylaniline is a clear liquid. easily turns light brown when exposed to air and light. It is an intermediate for dyes, organic pigments and pesticides.

• 反応プロフィール

  2,4,6-Trimethylaniline neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.

• 健康ハザード

  2,4,6-Trimethylaniline is moderately toxic orally. It is also considered highly toxic by unspecified routes. It is a skin and eye irritant. Suspect occupational carcinogen. (Non-Specific -- Aromatic Amines) The danger of acute poisoning is represented by methemoglobinemia leading to adverse effects on the red cells. A number of the amines may act as skin sensitizers.

• 火災危険

  When heated to decomposition, 2,4,6-Trimethylaniline emits toxic fumes of nitrogen oxides. Avoid decomposing heat.

• 安全性プロファイル

  Poison by inhalation. Moderately toxic by ingestion. A skin and severe eye irritant. Questionable carcinogen with experimental carcinogenic data. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.

• 合成

  2,4,6-Trimethylaniline (Mesidine) is synthesised from 2-Nitromesitylene through a reduction reaction. The reaction pathway is as follows:
  

• 職業ばく露

  Used on small scale in organic synthesis.

• 輸送方法

  UN2810 Toxic liquids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.

2,4,6-トリメチルアニリン 上流と下流の製品情報

2,4,6-トリメチルアニリン 生産企業

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2,4,6-トリメチルアニリン スペクトルデータ(¹HNMR、¹³CNMR、IR1、IR2、MS、Raman)

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