エメチン 塩酸塩

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Danger

• 危険有害性情報

  H300：飲み込むと生命に危険

  H315：皮膚刺激

  H319：強い眼刺激

• 注意書き

  P264：取扱い後は皮膚をよく洗うこと。

  P264：取扱い後は手や顔をよく洗うこと。

  P270：この製品を使用する時に、飲食または喫煙をしないこ と。

  P280：保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。

  P301+P310：飲み込んだ場合：直ちに医師に連絡すること。

  P302+P352：皮膚に付着した場合：多量の水と石鹸で洗うこと。

  P305+P351+P338：眼に入った場合：水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。

エメチン 塩酸塩 価格

エメチン 塩酸塩 化学特性,用途語,生産方法

• 外観

  白色～うすい赤黄色, 結晶性粉末～粉末

• 溶解性

  水にやや溶けやすい。

• 効能

  抗原虫薬, 催吐薬

• 使用上の注意

  アルゴン封入

• 化学的特性

  Emetine dihydrochloride is a colorless, combustible powder which turns yellow on exposure to heat or light.

• 使用

  Emetine dihydrochloride has been used:
  
  • as a protein synthesis inhibitor to study its effects on human papillomavirus type 8 E2 protein half-life
  • to study its effects on the stress granules assembly
  • as a chain-elongation inhibitor in puromycin assay for protein synthesis
  
  

• 一般的な説明

  Clusters of needles after drying at 221°F. Turns yellow on exposure to light or heat. An injectable form of emetine, an anti amebic. Emetine is the active ingredient of ipecac.

• 空気と水の反応

  Water soluble.

• 反応プロフィール

  When heated to decomposition, EMETINE DIHYDROCHLORIDE emits very toxic fumes of chlorides, hydrogen chloride and oxides of nitrogen. Turns yellow on exposure to light or heat [EPA, 1998].

• 健康ハザード

  EMETINE DIHYDROCHLORIDE is highly toxic orally. It is an eye irritant. (Non-Specific -- Emetine) Emetine is classified as extremely toxic. Probable oral lethal dose for humans is 5-50 mg/kg, or between 7 drops and one teaspoon for a 150-lb person.

• 火災危険

  When heated to decomposition, EMETINE DIHYDROCHLORIDE emits very toxic fumes of chlorides, hydrogen chloride and oxides of nitrogen. Turns yellow on exposure to light or heat

• 作用機序

  Epinephrine, a hormone having a benzenoid structure, C9H13O3N, also called adrenaline. It can be obtained by extraction from the adrenal glands of cattle and also prepared synthetically. Its effect on body metabolism is pronounced, causing an increase in blood pressure and rate of heartbeat. Under normal conditions, its rate of release into the system is constant, but emotional stresses, such as fear or anger rapidly increase the output and result in temporarily heightened metabolic activity. Epinephrine is used for the symptomatic treatment of bronchial asthma and reversible bronchospasm associated with chronic bronchitis and emphysema. The drug acts on both alpha and beta receptor sites. Beta stimulation provides bronchodilator action by relaxing bronchial muscle. Alpha stimulation increases vital capacity by reducing congestion of the bronchial mucosa and by constricting pulmonary vessels.
  Epinephrine has numerous effects on intermediary metabolism. Among these are promotion of hepatic glycogenolysis, inhibition of hepatic gluconeognesis, and inhibition of insulin release. The drug also promotes the release of free fatty acids from triglyceride stores in adipose tissues. Epinephrine produces numerous cardiovascular effects. Epinephrine is particularly useful in treating conditions of immediate hypersensitivity— interactions between antigen and antibody. These mechanisms cause attacks of anaphylaxis, hay fever, hives and allergic asthma. Anaphylaxis can occur after bee and wasp stings, venoms, etc. Although the mechanism is not fully understood, epinephrine can play a lifesaving role in the treatment of acute systemic anaphylaxis.

• 安全性プロファイル

  A poison by ingestion, intraperitoneal, subcutaneous, and intravenous routes. Human systemic effects: diarrhea, distorted perceptions, dyspnea, hallucinations, hypermothty, nausea or vomiting. A human eye irritant. When heated to decomposition it emits very toxic fumes of Cland NOx.

• 職業ばく露

  Emetine dihydrochloride is an injectable form of emetine; an alkaloid and antiamebic; the active ingredient of Ipecac. Emetine dihydrochloride is used as chemical reagent, organic intermediate; in pharmaceutical R&D

• 輸送方法

  UN1544 Alkaloids, solid, n.o.s. or Alkaloid salts, solid, n.o.s. poisonous, Hazard Class: 6.1; Labels: 6.1- Poisonous materials, Technical Name Required. UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1- Poisonous materials, Technical Name Required

• 純化方法

  It crystallises from MeOH/Et2O, MeOH or Et2O/EtOAc. The free base has m 104-105o, and the (-)-phenylthiourea derivative has m 220-221o (from EtOAc/pet ether, [] D -29.3o (CHCl3)). IR: 3413 (OH) and 2611 (NH+) cm-1; UV at 230nm ( 16 200) and 282nm ( 6 890) max max [Brossi et al. Helv Chim Acta 42 1515 1959, Barash et al. J Chem Soc 3530 1959]. [Beilstein 23 III/IV 3419.]

• 不和合性

  Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, and epoxides. Turns yellow on contact with light or heat

エメチン 塩酸塩 スペクトルデータ(IR1、MS)

316-42-7, エメチン 塩酸塩 キーワード