2-Fluoro-N-[2-(2-methyl-1H-indol-3-yl)ethyl]benzamide

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Warning

• 危険有害性情報

  H319：強い眼刺激

• 注意書き

  P264：取扱い後は皮膚をよく洗うこと。

  P264：取扱い後は手や顔をよく洗うこと。

  P280：保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。

  P305+P351+P338：眼に入った場合：水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。

2-Fluoro-N-[2-(2-methyl-1H-indol-3-yl)ethyl]benzamide 価格

2-Fluoro-N-[2-(2-methyl-1H-indol-3-yl)ethyl]benzamide 化学特性,用途語,生産方法

• 使用

  CK-666 may be used to study Arp2/3-mediated structural changes in cells.

• 一般的な説明

  A cell-permeable indolyl-fluorobenzamide compound that selectively inhibits actin assembly mediated by actin-related protein Arp2/3 complex of human, bovine, fission yeast S. pombe, and budding yeast S. cerevisiae origin (IC₅₀ = 4, 17, 5, and 12 μM, respectively), without affecting S. pombe formin domain Cdc12(FH2)-mediated or the spontaneous actin polymerization. Shown to inhibit the actin filament "comet tails" formation around intracellular Listeria in infected SKOV3 cells (IC₅₀ = 7 μM) in a reversible manner. Structrual studies indicate that CK-666 targets a pocket formed between subdomain 4 of Arp2 and subdomain 1 of Arp3, preventing Arp2/3 from shifting into an active conformation upon N-WASP-VCA binding. CK-666 and CK-869 (Cat. No. 182516) exhibit different modes of binding, resulting in their different yeast cross-reactivities. CK-689 (Cat. No. 182517) can serve as a negative control.

• Biochem/physiol Actions

  CK-666 binds to Arp2/3 complex, stabilizes the inactive state of the complex and prevents its movement into active conformation.

2-Fluoro-N-[2-(2-methyl-1H-indol-3-yl)ethyl]benzamide 生産企業

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442633-00-3, 2-Fluoro-N-[2-(2-methyl-1H-indol-3-yl)ethyl]benzamide キーワード