ANTI-LC3B ウサギ宿主抗体

ANTI-LC3B ウサギ宿主抗体 価格

ANTI-LC3B ウサギ宿主抗体 化学特性,用途語,生産方法

• 使用

  Anti-LC3B antibody produced in rabbit has been used in western blotting and immunohistochemistry.

• 一般的な説明

  Microtubule-associated protein 1 light chain 3 (MAPLC3/LC3) was first identified in rat as a protein that co-purifies with microtubule-associated protein 1A and 1B from rat brain. LC3 exists in cells in two forms. One is cytoplasmic, LC3-I (18 kDa) and the other, LC3-II (16 kDa) is associated with the autophagosome membrane. LC3-I is modified to a membrane-bound form, LC3-II (a LC3-phospholipid conjugate), by mammalian autophagy related protein 7 (Atg7) and Atg3, which are E1- and E2-like enzymes, respectively. Three human orthologs of the rat LC3, named MAP1LC3A/LC3A, MAP1LC3B/LC3B, and MAP1LC3C/ LC3C, were identified. The human proteins exhibit two forms representing the cytosolic (type I) and the membrane associated (type II) forms. The three human isoforms show different expression patterns in human tissues.

• Biochem/physiol Actions

  Microtubule-associated protein 1 light chain 3 (MAPLC3/LC3) expression level correlates with the extent of autophagosome formation. LC3B can be used as an autophagosomal marker.

ANTI-LC3B ウサギ宿主抗体 生産企業

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