MONOCLONAL ANTI-HPLK1 (POLO LIKE KINASE 1)

MONOCLONAL ANTI-HPLK1 (POLO LIKE KINASE 1) 価格

MONOCLONAL ANTI-HPLK1 (POLO LIKE KINASE 1) 化学特性,用途語,生産方法

• 使用

  Monoclonal Anti-hPlk1 (Polo Like Kinase 1) antibody produced in mouse has been used in:
  
  • enzyme linked immunosorbent assay (ELISA)
  • immunoblotting
  • immunoprecipitation
  • immunocytochemistry
  • immunofluorescence staining
  
  

• 一般的な説明

  Monoclonal Anti- hPlk1 (Polo Like Kinase 1) (mouse IgG2b isotype) is derived from the 35-206 hybridoma produced by the fusion of mouse myeloma cells (PAI) and splenocytes from BALB/c mice immunized with human full length Plk1. Polo-like kinases (Plks) are a family of serine/threonine kinases. The Plk family is structurally and functionally related to the polo gene in Drosophila. Plk1 localizes during mitosis in centrosomes, kinetochores and in the central spindle.

• Biochem/physiol Actions

  Polo Like Kinase 1 (Plk1) has a role in tumor progression. Plk1 is a target of the DNA damage checkpoint on the basis that its activity is inhibited by DNA damage in G2 and mitosis. Moreover, Plk1 was found to bind to the sequence-specific DNA binding domain of p53. This interaction between p53 and Plk1 inhibits the transcriptional activation and the proapoptotic functions of p53.

MONOCLONAL ANTI-HPLK1 (POLO LIKE KINASE 1) 生産企業

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