2-(4-クロロフェニル)-2-(1H-1,2,4-トリアゾール-1-イルメチル)ヘキサンニトリル

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Warning

• 危険有害性情報

  H302：飲み込むと有害

  H319：強い眼刺激

  H411：長期的影響により水生生物に毒性

• 注意書き

  P202：全ての安全注意を読み理解するまで取り扱わないこ と。

  P264：取扱い後は皮膚をよく洗うこと。

  P264：取扱い後は手や顔をよく洗うこと。

  P273：環境への放出を避けること。

  P301+P312：飲み込んだ場合：気分が悪い時は医師に連絡する こと。

  P305+P351+P338：眼に入った場合：水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。

  P308+P313：暴露または暴露の懸念がある場合：医師の診断/手当てを 受けること。

2-(4-クロロフェニル)-2-(1H-1,2,4-トリアゾール-1-イルメチル)ヘキサンニトリル 価格

MSDS Information

• alpha-Butyl-alpha-(4-chlorophenyl)-1H-1,2,4-triazole-1-propanenitrile

2-(4-クロロフェニル)-2-(1H-1,2,4-トリアゾール-1-イルメチル)ヘキサンニトリル 化学特性,用途語,生産方法

• 外観

  白色、結晶性粉末～粉末又は塊

• 溶解性

  水に殆ど不溶。アセトンに易溶。水142mg/l(25℃)。ケトン, エステル,アルコール, 芳香族炭化水素に50～100g/l溶ける。エタノールに溶け、水に極めて溶けにくい。

• 用途

  農薬(殺菌剤)

• 用途

  ミクロブタニル試験用標準品。

• 農薬用途

  殺虫剤

• 説明

  Myclobutanil is a broad-spectrum systemic foliar-applied fungicide of the substituted triazole chemical class of compounds, with protective, eradicative, and curative action. It disrupts membrane function in fungi by inhibition of sterol biosynthesis.
  It is produced by the alkylation of 4-chlorophenylacetonitrile with butyl chloride, followed by treatment with dibromomethane and sodium hydroxide in dimethyl sulfoxide. The resulting intermediate is then reacted with the potassium salt of 1,2,4-triazole in dimethyl formamide.
  Commercially, myclobutanil is presented as different formulations or preparations with concentrations up to 60% active ingredient (a.i.). It is formulated as a wettable powder (2–40% a.i.) or as an emulsifiable concentrate (1–25% a.i.), granular (<1% a.i.), dust (5% a.i.), dry flowable (60% a.i.), and ready to use (<1% a.i.) solutions to be used in agriculture or in domestic activities by homeowners.
  It is also used at lower concentrations in combination with other agrochemicals such as pyretroids (permethrin), fludioxonil, mefenoxam, azoxistrobin, mancozeb, sulfur, or fluoxastrobin.

• 化学的特性

  White to pale yellow crystalline solid. Soluble in alcohols, aromatics, esters, ketones and other organic solvents. Solubility is about 50-100g/L; insoluble in aliphatic hydrocarbons such as hexane; solubility in water is 142mg/L. The degradation half-life is 25 days in aqueous solution under sunlight, and 66 days in soil. It does not degrade under anaerobic conditions, and does not hydrolyze within 28 days under the conditions of pH 5, 7, and 9 (28°C).

• 使用

  Myclobutanil is an fungicide used on a wide range of food crops. Myclobutanil inhibits the biosynthesis of ergosterol, a critical componet of fungal cell membranes.

• 危険性

  Moderately toxic by ingestion, inhalation,and skin contact.

• 农业用途

  Fungicide: Widely used to control powdery mildew, rust, sclerotina, spot blight, rot, black rot and similar fungi on a variety of food and non-food crops.

• 製品名

  EAGLE®; NOVA®; NU-FLOW®; RALLY®; LAREDO®; RH 3866®; SYSTHANE® TECHNICAL

• 安全性プロファイル

  Moterately toxic by ingestion, inhalation, and skin contact. Experimental reproductive effects. When heated to decomposition emits toxic fumes of NOx, SO,, Cl-.

• 職業ばく露

  Myclobutanil is a nitrile compound and a triazole fungicide. It is widely used to control powdery mildew, rust, sclerotina, spot blight, rot, black rot and similar fungi on a variety of food and nonfood crops. Nitriles can be derived from salts of cyanide, but are usually less toxic.

• 環境運命予測

  Relevant physicochemical properties are estimated Koc value of 950, log Kow of 2.94, estimated Henry’s law constant of 4.3×10^-9 atmm³ mol^-1 at 25 ℃, vapor pressure of 1.6
  106 mmHg, and water solubility of 140 mg l^-1.
  In soil under aerobic conditions, myclobutanil exhibits high to very high persistence, and medium to low mobility, forming the minor soil metabolite myclobutanil butyric acid which exhibits low to moderate persistence and very high mobility in soil. Both adsorptions are affected significantly by differing soil pH. Volatilization from moist soil surfaces is not expected to be an important fate process. The biodegradation half-life of myclobutanil in silt loam soil is about 66 days. No degradation was observed under anaerobic conditions.
  In aquatic environments, it is expected to adsorb to suspended solids and sediment. Volatilization from water surfaces is not expected. In dark natural sediment water systems, myclobutanil partitioned from the water column to sediment, where it exhibited very high persistence. Aqueous solutions of myclobutanil decompose on exposure to light with half-lives of 222 days in sterile water, 0.8 days in sensitized sterile water, and 25 days in pond water. Hydrolysis was not observed after 28 days at pH values of 5, 7, and 9 at 28 ℃.
  An estimated bioconcentration factor of 37 suggests the potential for bioconcentration in aquatic organisms is moderate, provided the compound is not metabolized by the organism.
  In the ambient atmosphere, it is expected to exist in both the vapor and particulate phases. Vapor-phase myclobutanil is degraded by reaction with photochemically produced hydroxyl radicals; the half-life for this reaction in air is estimated to be 2.3 days. Particulate-phase myclobutanil may be removed from the air by wet or dry deposition.

• 代謝経路

  There is limited published information available on the metabolism of myclobutanil. In plants and mammals, the butyl group is oxidised to an alcohol and a ketone. In soils, substantial degradation of the molecule occurs under aerobic conditions.

• 輸送方法

  UN2763 Triazine pesticides, solid, toxic, Hazard Class: 6.1; Labels: 6.1-Poisonous materials. UN3077 Environmentally hazardous substances, solid, n.o.s., Hazard class: 9; Labels: 9-Miscellaneous hazardous material, Technical Name Required. UN3082 Environmentally hazardous substances, liquid, n.o.s., Hazard class: 9; Labels: 9-Miscellaneous hazardous material, Technical Name Required.

• 不和合性

  Decomposes on exposure to strong light. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides. The triazoles are sensitive to heat, friction, and impact. Sensitivity varies with the type substitution to the triazole ring. Metal chelated and halogen substitution of the triazole ring make for a particularly heat sensitive material. Azido and nitro derivatives have been employed as high explosives. No matter the derivative these materials should be treated as explosives. Nitriles may polymerize in the presence of metals and some metal compounds. They are incompatible with acids; mixing nitriles with strong oxidizing acids can lead to extremely violent reactions. Nitriles are generally incompatible with other oxidizing agents such as peroxides and epoxides. The combination of bases and nitriles can produce hydrogen cyanide. Nitriles are hydrolyzed in both aqueous acid and base to give carboxylic acids (or salts of carboxylic acids). These reactions generate heat. Peroxides convert nitriles to amides. Nitriles can react vigorously with reducing agents. Acetonitrile and propionitrile are soluble in water, but nitriles higher than propionitrile have low aqueous solubility. They are also insoluble in aqueous acids.

• 廃棄物の処理

  Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Contact a licensed disposal facility about surplus and nonrecyclable solutions. Burn in a chemical incinerator equipped with an afterburner and scrubber. Extra care must be exercised as the material in an organic solvent is highly flammable. In accordance with 40CFR165, follow recommendations for the disposal of pesticides and pesticide containers. Containers must be disposed of properly by following package label directions or by contacting your local or federal environmental control agency, or by contacting your regional EPA office. Incineration or permanganate oxidation.

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2-(4-クロロフェニル)-2-(1H-1,2,4-トリアゾール-1-イルメチル)ヘキサンニトリル スペクトルデータ(¹HNMR)

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