4,6-ジニトロ-o-クレゾール (約20% 水湿潤品)

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Danger

• 危険有害性情報

  H315：皮膚刺激

  H317：アレルギー性皮膚反応を起こすおそれ

  H318：重篤な眼の損傷

  H341：遺伝性疾患のおそれの疑い

  H410：長期的影響により水生生物に非常に強い毒性

• 注意書き

  P201：使用前に取扱説明書を入手すること。

  P273：環境への放出を避けること。

  P280：保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。

  P305+P351+P338：眼に入った場合：水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。

4,6-ジニトロ-o-クレゾール (約20% 水湿潤品) 価格

4,6-ジニトロ-o-クレゾール (約20% 水湿潤品) 化学特性,用途語,生産方法

• 外観

  うすい黄色〜だいだい褐色, 結晶〜粉末

• 溶解性

  水6.94g/l(20℃,pH7)。トルエン251、メタノール58.4、ヘキサン4.03、酢酸エチル338、アセトン514、ジクロロメタン503（g/l,20℃)アセトンに溶ける。

• 用途

  農薬(殺虫劑、殺菌劑、除草劑)

• 用途

  DNOC試験用標準品。

• 化学的特性

  yellow to yellow-green crystals or cryst. powder

• 使用

  2-Methyl-4,6-dinitrophenol can be used as dormant ovicidal spray for fruit trees (highly phytotoxic and cannot be used successfully on actively growing plants); herbicide; insecticide.

• 調製方法

  o-Cresol is sulfonated in excess 75 % sulfuric acid to give the disulfonic acid. The sulfonation mass is diluted with water, and 2 equivalents of nitric acid are added at 70 ℃ to form the dinitro derivative. The product is separated while molten and washed with hot water.

• 定義

  ChEBI: A hydroxytoluene that is o-cresol carrying nitro substituents at positions 4 and 6.

• 一般的な説明

  A yellow solid. Emits toxic oxides of nitrogen fumes when heated to decomposition. Toxic by skin absorption, inhalation or ingestion. Soluble in alcohol, acetone, ether and solutions of sodium or potassium hydroxides.

• 空気と水の反応

  Slightly soluble in water.

• 健康ハザード

  Extremely toxic material; probable oral lethal dose is 5-50 mg/kg in humans or between 7 drops and 1 teaspoonful for a 70 kg (150 lb.) person.

• 火災危険

  Combustible material: may burn but does not ignite readily. When heated, vapors may form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated. Runoff may pollute waterways. Substance may be transported in a molten form.

• 农业用途

  Herbicide, Fungicide, Pesticide: DNOC is widely used in agriculture as a herbicide and pesticide; it is also used in the dyestuff industry. Although 4,6-dinitro-o-cresol (DNOC) is no longer registered for use in the United States, it was used as a blossom-thinning agent on fruit trees and as a fungicide, insecticide, and miticides on fruit trees during the dormant season. It is used in mushroom houses to control foreign fungi; to kill locusts and other insects; and as a pre-harvest desiccant of potatoes and leguminous seed crops. DNOC is used as free radical polymerization inhibitor and agricultural chemical intermediate; widely used in agriculture as a herbicide and pesticide; Hence, individuals formulating or spraying the compound incur the highest risk of exposure to the compound. Not approved for use in EU countries. DNOC’s registration in the U.S. as a pesticide was canceled in 1991. Currently, there are 39 global suppliers.

• 製品名

  ANTINONIN®; ANTINONNIN®; ARBOROL®; DEGRASSAN®; DEKRYSIL®; DETAL®; DILLEX®; DINOC®; DINURANIA®; DITROSOL®; DNOC®[C]; EFFUSAN®; EFFUSAN 3436®; ELGETOL®; ELGETOL 30®; ELIPOL®; EXTRAR®; FLAVIN-SANDOZ®; HEDOLIT®; HEDOLITE®; K III®; K IV®; KREOZAN®; KREZOTOL 50®; LIPAN®; NEUDORFF DN 50®; NITROFAN®; PROKARBOL®; RAFEX®; RAFEX 35®; RAPHATOX®; SANDOLIN®; SANDOLIN A®; SELINON®; SINOX®; WINTERWASH®

• 安全性プロファイル

  Human poison by unspecified route. Experimental poison by ingestion, inhalation, skin contact, intraperitoneal, and intravenous routes. Human systemic effects by ingestion and inhalation: somnolence, headache, abnormal brain recordings from specific areas of the central nervous system, cardlac and gastrointestinal changes. Mutation data reported. An e~7e and skin irritant. Less toxic than the para form, but is still highly toxic. A pesticide. See also NITRO COMPOUNDS of AROMATIC HYDROCARBONS and other dinitrocresol entries.

• 発がん性

  In one chronic feeding study in rats DNOC did not cause an increased incidence of any type of tumor. DNOC was clastogenic, increasing the frequency of chromosomal aberrations both in vivo and in vitro. Conflicting results for mutagenicity have been obtained in bacterial assays.
  The 2003 ACGIH threshold limit valuetime- weighted average (TLV-TWA) for dinitro-o-cresol is 0.2mg/m3 with a notation for skin absorption.

• 環境運命予測

  Soil/Plant. In plants and soils, the nitro groups reduced to amino groups (Hartley and Kidd, 1987). When 4,6-dinitro-o-cresol was statically incubated in the dark at 25°C with yeast extract and settled domestic wastewater inoculum, no signi?cant biodegradation and necessary acclimation for optimum biooxidation within the 4-week incubation period was observed (Tabak et al., 1981).
  Chemical/Physical. 4,6-Dichloro-o-cresol will react with amines and alkali metals forming water-soluble salts which are indicative of phenols (Morrison and Boyd, 1971).

• 代謝経路

  DNOC is metabolised in soils, plants and animals via common metabolic pathways. The primary reaction is the reduction of the nitro groups to the corresponding amino-analogues. Acetylation and deamination via hydroxylation/elimination follow. N- and O-Conjugation as glucosides and glucuronides occurred in plants and animals. The metabolic pathways of DNOC are presented in Scheme 1.

• 純化方法

  The cresol crystallises from aqueous EtOH. [Beilstein 6 H 369, 6 III 1276.]

4,6-ジニトロ-o-クレゾール (約20% 水湿潤品) 上流と下流の製品情報

4,6-ジニトロ-o-クレゾール (約20% 水湿潤品) スペクトルデータ(¹HNMR、IR1、IR2、MS)

534-52-1, 4,6-ジニトロ-o-クレゾール (約20% 水湿潤品) キーワード