rac-(R*)-1-(3-クロロフェニル)-2-[(1,1-ジメチルエチル)アミノ]-1-プロパノン/塩酸,(1:1)

化学名:rac-(R*)-1-(3-クロロフェニル)-2-[(1,1-ジメチルエチル)アミノ]-1-プロパノン/塩酸,(1:1)

CAS番号.31677-93-7

英語名:Bupropion hydrochloride

CBNumberCB5140066

MFC13H19Cl2NO

MW276.2

MOL File31677-93-7.mol

别名

ウェルバトリン

アンフェブタモン塩酸塩

塩酸ブプロピオン

rac-(R*)-1-(3-クロロフェニル)-2-[(1,1-ジメチルエチル)アミノ]-1-プロパノン/塩酸,(1:1)物理性質

融点	233-234 °C
闪点	9℃
貯蔵温度	Desiccate at RT
溶解性	エタノール: 193 mg/mL の溶液は、4 °C で数日間保存できます。
外見	個体
色	白い
水溶解度	水に可溶 (>25mg/ml)、エタノール 193mg/ml、0.1NHCl 333mg/ml
CAS データベース	31677-93-7(CAS DataBase Reference)

安全性情報

主な危険性	Xn,Xi,T,F
Rフレーズ	22-39/23/24/25-23/24/25-11
Sフレーズ	36-45-36/37-16-7
RIDADR	UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany	3
RTECS 番号	UG8858000
HSコード	29223990

危険有害性情報のコード(GHS)

rac-(R*)-1-(3-クロロフェニル)-2-[(1,1-ジメチルエチル)アミノ]-1-プロパノン/塩酸,(1:1) 化学特性,用途語,生産方法

化学的特性
Bupropion hydrochloride powder is white, crystalline, and highly soluble in water. It has a bitter taste and produces the sensation of local anesthesia on the oral mucosa.
薬物相互作用
Relatively few data are available on interactions of bupropion hydrochloride with other drugs. Increased adverse experiences were reported when the drug was administered concomitantly with l-dopa. MAOIs may increase the acute toxicity of bupropion.
Although bupropion is not metabolized by the CYP2D6 enzyme, the drug and its metabolite, morpholinol, inhibit this enzyme in vitro. Therefore, extreme caution should be exercised when coadministering any drug metabolized by that enzyme, and initial dosage of the drug should be as low as possible.
使用
Bupropion hydrochloride is indicated for the treatment of MDD. Bupropion hydrochloride SR (Zyban) is indicated as an aid to smoking cessation treatment.
生物活性
Non-selective inhibitor of dopamine and noradrenalin transporters (K i values are 1.4, 2.8 and 45 μ M for NET, DAT and SERT transporters respectively). Also inhibits neuronal nicotinic acetylcholine receptors. Displays antidepressant activity and augments nicotine self-administration at low doses in vivo .
副作用
Bupropion hydrochloride can cause serious side effects. The most common side effects of Bupropion hydrochloride include:
headache
dizziness
dry mouth
sore throat
nausea
constipation
trouble sleeping
Mode of action
The exact mechanism of the antidepressant action of bupropion is not known, but is presumed to be related to noradrenergic and/or dopaminergic mechanisms. Bupropion is a relatively weak inhibitor of the neuronal reuptake of norepinephrine and dopamine, and does not inhibit the reuptake of serotonin. Bupropion does not inhibit monoamine oxidase.

rac-(R*)-1-(3-クロロフェニル)-2-[(1,1-ジメチルエチル)アミノ]-1-プロパノン/塩酸,(1:1) 上流と下流の製品情報

31677-93-7, rac-(R*)-1-(3-クロロフェニル)-2-[(1,1-ジメチルエチル)アミノ]-1-プロパノン/塩酸,(1:1) キーワード

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