ソランカルピジンともいう

ソランカルピジンともいう 価格

ソランカルピジンともいう 化学特性,用途語,生産方法

• 解説

  ソランカルピジンともいう，ジャガイモSolanum，aculeatissinum，S.cyananthumなどに含まれるステロイドアルカロイド配糖体ソラソニン(solasonine)のアグリコン．

• 説明

  There is still some doubt as to whether this base occurs as such in Solanum aviculare and S. xanthocarpum or whether it is an artifact formed from Sola_x0002_sonine (q.v.) during the extraction process. The base is laevorotatory having [α]²⁰_D - 92.4° (C6H6) and the following salts and derivatives have been prepared: hydrochloride, m.p. 314°C; hydriodide, m.p. 293°C; oxalate, m.p. 248°C; tartrate, m.p. 222°C; picrate, m.p. 1.4l-2°C; picrolonate, m.p. 234°C; acetyl derivative, m.p. 195°C; benzoyl compound, m.p. 2l6-7°C and the 3:5-dinitrobenzoyl derivative, m.p. 191.5-193°C. The alkaloid forms a sparingly soluble digitonide and yields Diels's hydrocarbon on selenium dehydrogenation.

• 使用

  Solasodine is a potentially useful precursor for steroidal compounds and hormones, this is usually found in plants from the solanaceae family. It also has potent cytotoxic and anti-inflammatory effects.

• 一般的な説明

  This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG

• 安全性プロファイル

  Poison by intraperitoneal route. Moderately toxic by ingestion. Experimental teratogenic and reproductive effects. When heated to decomposition it emits toxic fumes of NOx.

• 純化方法

  Solasodine crystallises (as monohydrate) from MeOH as lustrous plates (on heating, the plates change to needles as they melt and resolidify in needles), or aqueous 80% EtOH, and sublimes at high vacuum. After recrystallisation from H2O, m 198-199o, then from Me2CO/H2O, m 199-201o, it has [] D 22 -109.3o (c 0.581, CHCl3). On TLC with silica gel G (*C6H6/absolute EtOH, 8:2) it has RF 0.45. IR (KBr): max at 10.3, 10.4, 11.2, 11.5 (azaoxaspirane bands). [Schreiber & Rnsch Tetrahedron 20 1939 1964, Uhle J Org Chem 27 656 1962, Kessar et al. Tetrahedron 27 2153 1971, Beilstein 27 III/IV 2000.]

• 参考文献

  Rochelmeyer, Chen., Arch. Pharm., 277,329 (1939)
  Briggs., J. Chem. Soc., 3, (1942)
  Briggs et al., ibid, 3013 (1950)
  Absolute configuration: Boll, Phillipsborn., Acta Chem. Scand., 19, 1365 (1965)
  Synthesis: Schreiber, Walther, Ronsch., Tetrahedron, 20, 1939 (1964)
  Adam, Schreiber., Experientia, 21,471 (1965)
  Adam, Schreiber., Tetrahedron, 22,3591 (1966)

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