トリフルオロ酢酸

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Danger

• 危険有害性情報

  H314：重篤な皮膚の薬傷?眼の損傷

  H332：吸入すると有害

  H412：長期的影響により水生生物に有害

• 注意書き

  P261：粉じん/煙/ガス/ミスト/蒸気/スプレーの吸入を避ける こと。

  P273：環境への放出を避けること。

  P280：保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。

  P303+P361+P353：皮膚（または髪）に付着した場合：直ちに汚染された衣 類をすべて脱ぐこと/取り除くこと。皮膚を流水/シャワー で洗うこと。

  P305+P351+P338：眼に入った場合：水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。

トリフルオロ酢酸 価格

MSDS Information

• Trifluoroacetic acid

トリフルオロ酢酸 化学特性,用途語,生産方法

• 外観

  無色澄明の液体

• 溶解性

  水及びエタノールと任意の割合で混和する。

• 解説

  トリフルオロ酢酸，トリフルオロサクサン，塩化アセチルの電解フッ素化により得られるトリフルオロアセチルフルオリドより合成される．刺激臭をもつ発煙性の液体．沸点72～72.5 ℃．－15.3 ℃ で固化して無色の板状結晶になる．d⁰1.5351．n_D²⁰1.2850．pKa 0.23．トリクロロ酢酸より強酸性である．吸湿性．水およびほとんどの有機溶媒に可溶．100 ℃ で五酸化リンと加熱すると無水トリフルオロ酢酸(CF3CO)2Oを生成する．種々の有機合成反応用溶媒に用いられる．刺激性，腐食性，毒性がある．

• 用途

  アミノ酸配列分析用試薬。

• 用途

  ペプチド合成におけるアミノ酸切り出し用。

• 用途

  PSQ-1等システム専用試液。

• 用途

  HPLC分析用溶離液調製用。誘導体調製用。

• 用途

  有機合成原料、調製液原料、医薬・農薬中間体。

• 用途

  医薬?農薬中間体,触媒,核磁気共鳴分析試薬

• 用途

  島津全自動タンパク質一次構造分析装置(PSQ-1, PSQ-2, PPSQ-10)用試薬〉。

• 使用上の注意

  不活性ガス封入

• 化学的特性

  Trifluoroacetic acid (TFA) is an analogue of acetic acid with the three hydrogen atoms replaced by three fluorine atoms. It has a vinegar-like odor and is a strong acid, a good solvent and has excellent reactive properties. The specific gravity of liquid TFA is 1.48 and it boils at 72 °C. Trifluoroacetic Acid is a solvent that is used in the production of pharmaceutical and agricultural chemicals as well as in many other specialized applications. Some of the more popular uses for TFA are as a silyl catalyst when derivatizing carbohydrates, as a reagent for purifying large peptides, as an ion pair reagent, and as an LC mobile phase additive.

• 使用

  Trifluoroacetic acid is an important building block in the synthesis of pharmaceuticals, agrochemicals and performance products. It is a precursor to many fluorinated compounds, and widely used in peptide synthesis and other organic transformations involving deprotection of t-BOC group. The combination of properties like solubility in most of the solvents, volatility, catalytic property, and strong acidity with non-oxidizing nature makes it a widely used reagent in organic synthesis. Trifluoroacetic acid can use as an ion pairing agent in liquid chromatography, as a solvent in NMR spectroscopy and as a calibrant in mass spectrometry. It is used as a catalyst in esterification reaction and condensation reaction and a protective agent for hydroxyl and amino.

• 定義

  ChEBI: Trifluoroacetic acid is a monocarboxylic acid that is the trifluoro derivative of acetic acid. It has a role as a reagent and a human xenobiotic metabolite. It derives from an acetic acid. It is a conjugate acid of a trifluoroacetate.

• 一般的な説明

  Trifluoroacetic acid appears as a colorless fuming liquid with a pungent odor. Soluble in water and denser than water. Corrosive to skin, eyes and mucous membranes. Used to make other chemicals and as a solvent.

• 空気と水の反応

  Fumes in air. Soluble in water.

• 反応プロフィール

  Trifluoroacetic acid is a strong acid; attacks many metals [Handling Chemicals Safely 1980. p. 935]. A 30% solution of hydrogen peroxide in Trifluoroacetic acid is often used to destructively oxidize aromatic rings in preference to the side chains. Explosions have occurred, if the excess peroxide is not catalytically destroyed, prior to removal of solvent, [Tetrahedron Lett., 1977, 1703-1704]. The reduction of amides of Trifluoroacetic acid with lithium aluminum hydride are dangerous at all phases of the process, explosions have occurred, [Chem. Eng. News, 1955, 33, 1368].

• 健康ハザード

  Trifluoroacetic acid is a highly corrosive substance. Contact of the liquid with the skin, eyes, and mucous membranes can cause severe burns, and ingestion can result in serious damage to the digestive tract. TFA vapor is highly irritating of the eyes and respiratory tract, and inhalation of high concentrations can lead to severe destruction of the upper respiratory tract and may be fatal as a result of pulmonary edema. Symptoms of overexposure to TFA vapor include a burning feeling, coughing, headache, nausea, and vomiting.
  Trifluoroacetic acid has not been found to be carcinogenic or to show reproductive or developmental toxicity in humans.

• 火災危険

  Trifluoroacetic acid is not combustible. Nevertheless, the presence of trifluoroacetic acid at the site of a fire would be of great concern because of its high vapor pressure and extreme corrosiveness. Some are oxidizers and may ignite combustibles (wood, paper, oil, clothing, etc.). Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated.

• 安全性プロファイル

  Poison by ingestion and intraperitoneal routes. Moderately toxic by intravenous route. Mildly toxic by inhalation. A corrosive irritant to skin, eyes, and mucous membranes. When heated to decomposition it emits toxic fumes of F-. Used as a strong organic acid catalyst.

• 貯蔵

  trifluoroacetic acid should be stored in an acid cabinet away from other classes of compounds. Because of its high vapor pressure, fumes of trifluoroacetic acid can destroy labels on other bottles if the container is not tightly sealed.

• 純化方法

  The purification of trifluoroacetic acid, reported in earlier editions of this work, by refluxing over KMnO4 for 24hours and slowly distilling has resulted in very SERIOUS EXPLOSIONS on various occasions, but not always. This apparently depends on the source and/or age of the acid. The method is NOT RECOMMENDED. Water can be removed by adding trifluoroacetic anhydride (0.05%, to diminish water content) and distilling. [Conway & Novak J Phys Chem 81 1459 1977]. It can be refluxed and distilled from P2O5. It is further purified by fractional crystallisation by partial freezing and again distilled. Highly TOXIC vapour. Work in an efficient fume hood. [Beilstein 2 IV 458.]

• 不和合性

  Mixing trifluoroacetic acid and water evolves considerable heat.

• 廃棄物の処理

  Trifluoroacetic acid and waste material containing this substance should be placed in an appropriate container, clearly labeled, and handled according to your institution's waste disposal guidelines.

トリフルオロ酢酸 上流と下流の製品情報

トリフルオロ酢酸 生産企業

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トリフルオロ酢酸 スペクトルデータ(IR1、MS)

76-05-1, トリフルオロ酢酸 キーワード