4'-ニトロアセトフェノン

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Warning

• 危険有害性情報

  H301：飲み込むと有毒

  H302：飲み込むと有害

• 注意書き

  P264：取扱い後は皮膚をよく洗うこと。

  P264：取扱い後は手や顔をよく洗うこと。

  P270：この製品を使用する時に、飲食または喫煙をしないこ と。

  P321：特別な処置が必要である（このラベルの．．． を見よ）。

  P405：施錠して保管すること。

  P501：内容物/容器を．．．に廃棄すること。

4'-ニトロアセトフェノン 価格

MSDS Information

• 1-(4-nitrophenyl)ethanone

4'-ニトロアセトフェノン 化学特性,用途語,生産方法

• 外観

  うすい黄色～黄褐色、結晶～結晶性粉末又は塊

• 溶解性

  アセトン及びエタノールに溶け、水に難溶である。

• 化学的特性

  The pure product is pale yellow crystal or needle crystal. Soluble in hot ethanol, ether and benzene, insoluble in water. 4-Nitroacetophenone is the raw material for the manufacture of synthomycin and chloramphenicol.

• 使用

  4''-Nitroacetophenone is used as a reagent in the synthesis of 4-Nitroacetophenone thiosemicarbazone derivatives and their copper(II) complexes which have potential anti-trypanosomal activity in vitro. Also used as a reagent in the synthesis of (R)-(4-Nitrophenyl)oxirane (N504430) and (S)-(4-Nitrophenyl)oxirane (N504435).

• 製造方法

  In the presence of catalyst cobalt stearate, p-nitroethylbenzene is oxidized to synthesize 4-nitroacetophenone with air at 140-150°C and 0.2MPa pressure. The reaction product is washed with water, neutralized, centrifugally dehydrated, and dried to obtain a finished product.

• 定義

  ChEBI: 4-nitroacetophenone is a member of the class of acetophenones that is acetophenone substituted at the para-position by a nitro group. It is a C-nitro compound and a member of acetophenones.

• 主な応用

  One of several alternative routes to synthetic chloroamphenicol uses 4-nitroacetophenone as starting material with a first-stage bromination to α-bromo-4-nitroacetophenone followed by buildup of the side chain. α-bromo-4-nitroacetophenone is the key precursor in the synthesis of the bronchodilator clenbuterol.

• 一般的な説明

  P-nitroacetophenone appears as yellow prisms or bright yellow powder. (NTP, 1992)

• 空気と水の反応

  Insoluble in water.

• 反応プロフィール

  A nitrated ketone. Ketones are reactive with many acids and bases liberating heat and flammable gases (e.g., H2). The amount of heat may be sufficient to start a fire in the unreacted portion of the ketone. Ketones react with reducing agents such as hydrides, alkali metals, and nitrides to produce flammable gas (H2) and heat. Ketones are incompatible with isocyanates, aldehydes, cyanides, peroxides, and anhydrides. They react violently with aldehydes, HNO3, HNO3 + H2O2, and HClO4.

• 火災危険

  Flash point data for 4-Nitroacetophenone are not available. 4-Nitroacetophenone is probably combustible.

• 純化方法

  Crystallise the ketone from EtOH or aqueous EtOH. [Beilstein 7 IV 657.]

4'-ニトロアセトフェノン 上流と下流の製品情報

4'-ニトロアセトフェノン 生産企業

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4'-ニトロアセトフェノン スペクトルデータ(¹HNMR、¹³CNMR、IR1、IR2、IR3、MS、Raman)

100-19-6, 4'-ニトロアセトフェノン キーワード