Dalfopristin+Quinupristin

Dalfopristin+Quinupristin 化学特性,用途語,生産方法

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  A drug combination of the streptogramins, quinupristin and dalfopristin was approved for IV use in the treatment of infections caused by vancomycin-resistant Enterococcus faeci um bacteremia as well as skin/skin structure infections caused by MRSA and methicillin-sensitive Streptococcus pyogenes. Certain strains of E. faecium are resistant to essentially all other antibiotics, including vancomycin. The streptogramin type A compound dalfopristin binds to the 50S ribosomal subparticle, resulting in a conformational change in the substrate. It appears that dalfopristin binding creates a high-affinity binding site for quinupristin, accounting for the synergy.

Dalfopristin+Quinupristin 生産企業

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