Rituximab 化学特性,用途語,生産方法
-
説明
Rituximab is a genetically engineered, fused mouse/human anti-CD40 monoclonal antibody that targets B lymphocytes by binding specifically to CD20 antigen, a protein found on the surface of B cells at certain stages in their life cycle. Rituximab is composed of two heavy chains of 451 amino acids and two light chains of 213 amino acids with an approximate molecular weight of 145 kDa. Its binding affinity for the CD20 antigen is approximately 8.0 nM. -
使用
Antineoplastic (microtubule inhibitor); monoclonal antibody. -
一般的な説明
Rituximab (Rituxan, Chimeric) is an MAb directed againstthe CD20 antigen expressed on the surfaces of normal andmalignant B lymphocytes. The MAb is produced in mammalian(CHO) suspension culture and is a chimeric(murine/human) MAb of the IgG1 κ type. The protein is composed of murine light and heavy chain variable regionsand human constant regions. Rituximab is indicated for thetreatment of patients with relapsed or refractory, low-gradeor follicular, CD20(+) B-cell non-Hodgkin lymphoma.Rituximab binds specifically to antigen CD20 (human Blymphocyte–restricted differentiation antigen, a hydrophobictransmembrane protein expressed on pre-B and matureB lymphocytes). CD20 is a protein of 35 to 37 kDa, and itmay play a role in B cell activation and regulation and maybe a calcium ion channel. The antigen is also expressed onmore than 90% of non-Hodgkin lymphoma B cells but is notfound on hematopoietic stem cells, pro-B cells, normalplasma cells, or other normal tissues. CD20 regulates theearly steps in the activation process for cell cycle initiationand differentiation. -
臨床応用
Rituximab is a sterile, clear, colorless, preservative-free, liquid concentrate formulated for IV administration. It has changed the treatment of rheumatoid arthritis by showing that targeted B-cell therapy in combination with methotrexate can reduce signs and symptoms of rheumatoid arthritis in adult patients with moderately to severely active rheumatoid arthritis who have had an inadequate response to one or more TNF antagonist therapies. Although B cells once were considered to be one of the main contributing factors in the pathogenesis of rheumatoid arthritis, recent evidence has shown that Tcells, dendritic cells, and macrophages also were involved. Rituximab has rekindled interest in B cells, highlighting their important role in perpetuating the inflammatory process and showing how they may interact with other cell types and contribute to joint inflammation. -
副作用
Side effects include flu-like signs and symptoms such as fever, chills, and nausea. Some people experience an “infusion-reaction complex,” such as difficulty breathing and heart problems, that has resulted in fatalities.
Rituximab 生産企業
Global(17)Suppliers
-
Wuhan Sunrise Technology Development Co., Ltd.
電話番号 027-027-83314682<br/>13554138826
電子メール whsrtech@vip.163.com
-
Beijing HuaMeiHuLiBiological Chemical
電話番号 010-56205725
電子メール waley188@sohu.com
-
Shanghai Lollane Biological Technology Co.,Ltd.
電話番号 021-52996696,15000506266<br/>15000506266
電子メール
-
Shanghai Synchem Pharma Co., ltd
電話番号 21-619849051-1<br/>18016477331
電子メール synchempharma@aliyun.com
-
Shanghai Hanjing Chemicals Co., Ltd.
電話番号 021-54285032<br/>13641685631
電子メール gerry.shu@hanjingchemicals.com