3-[6-[4-(トリフルオロメトキシ)アニリノ]ピリミジン-4-イル]ベンズアミド

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Warning

• 危険有害性情報

  H315：皮膚刺激

  H319：強い眼刺激

  H335：呼吸器への刺激のおそれ

• 注意書き

  P261：粉じん/煙/ガス/ミスト/蒸気/スプレーの吸入を避ける こと。

  P305+P351+P338：眼に入った場合：水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。

3-[6-[4-(トリフルオロメトキシ)アニリノ]ピリミジン-4-イル]ベンズアミド 価格

3-[6-[4-(トリフルオロメトキシ)アニリノ]ピリミジン-4-イル]ベンズアミド 化学特性,用途語,生産方法

• 説明

  GNF-2 is an allosteric inhibitor of Bcr-Abl (IC₅₀ = 267 nM). It is selective for Bcr-Abl over c-Abl and a panel of 63 additional kinases at 10 μM. It inhibits proliferation of Ba/F3 cells (IC₅₀ = 138 nM). GNF-2 (10 μM) reduces viral titers in Vero cells infected with infectious bronchitis virus (IBV), a coronavirus, via inhibition of IBV surface glycoprotein-induced syncytia formation and virus-cell fusion. It inhibits LPS-induced production of nitric oxide (NO) and TNF-α in BV-2 microglia when used at concentrations of 10 and 20 μM. GNF-2 (1 and 10 mg/kg) reduces paw edema and increases the latency to paw withdrawal in a mouse model of inflammatory pain induced by complete Freund’s adjuvant (CFA). It also decreases mechanical and thermal hyperalgesia in a mouse model of diabetic neuropathy induced by streptozotocin (STZ; ).

• 使用

  Bcr-abl Inhibitor is an inhibitor of c-Abl and Bcr-abl activity. It is a COVID19-related research product.

• 一般的な説明

  A cell-permeable and reverisble pyrimidine compound that binds to the c-abl myristoyl binding pocket and acts as an allosteric, non-ATP-competitive inhibitor of cellular Bcr-abl activity and Bcr-abl-dependent cellular functions. Exhibits little inhibitory effect against a panel of 63 kinases even at concentration as high as 10 μM. Exhibits potent and selective antiproliferative activity toward Bcr-abl-expressing cells (IC₅₀ = 138 nM, 194 nM, 268 nM and 273 nM in Ba/F3.p210, Ba/F3.p^185Y253H, SUP-B15 and Ba/F3.p^210E255V, and K562, respectively). Brij-35 is reported to mask the inhibitory effect of GNF-2 in cell-free c-abl and Bcr-abl kinase assays.

3-[6-[4-(トリフルオロメトキシ)アニリノ]ピリミジン-4-イル]ベンズアミド 生産企業

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3-[6-[4-(トリフルオロメトキシ)アニリノ]ピリミジン-4-イル]ベンズアミド スペクトルデータ(¹HNMR)

778270-11-4, 3-[6-[4-(トリフルオロメトキシ)アニリノ]ピリミジン-4-イル]ベンズアミド キーワード