2.5S 神経細胞成長因子, マウス顎下腺由来

2.5S 神経細胞成長因子, マウス顎下腺由来 価格

2.5S 神経細胞成長因子, マウス顎下腺由来 化学特性,用途語,生産方法

• 使用

  Nerve Growth Factor-7S (NGF-7S) from murine submaxillary gland has been used for the treatment of following cells to induce neuronal differentiation-
  
  • PC12
  • Dorsal root ganglia (DRG) obtained from chick embryos of either sex (Gallus gallus)

• 一般的な説明

  Nerve growth factor (NGF) is a dimer of 118-residue polypeptide chains linked non-covalently. Both these polypeptides contain three intramolecular disulphide bridges. It forms the prototype of the neurotrophin growth factor family. In male mouse submandibular salivary gland, NGF is present in high amounts, and is present as a high molecular weight complex called nerve growth factor-7S (NGF-7S). NGF-7S is an α₂β₂γ₂ complex, where β₂-NGF is the active neurotrophin, and is linked to the dimers of the glandular kallikrein serine proteinases members, α-NGF and γ-NGF.

• Biochem/physiol Actions

  Nerve growth factor (NGF) is a neurotrophin, which facilitates the differentiation and survival of specific subtypes of neurons of central nervous system and peripheral nervous system. However, nerve growth factor-7S (NGF-7S) lacks any neurotrophic activity as most part of β-NGF subunit is buried within the NGF-7S complex.

2.5S 神経細胞成長因子, マウス顎下腺由来 生産企業

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