腫瘍壊死因子-Α 化学構造式

腫瘍壊死因子-Α

化学名:腫瘍壊死因子-Α

CAS番号.94948-59-1

英語名:HUMAN TNF-ALPHA

CBNumberCB4704832

MFNULL

MW0

MOL FileMol file

别名

腫瘍壊死因子-Α

腫瘍壊死因子-Α,(TNF-Α) ヒト, 組換え体

腫瘍壊死因子-Α(TNF-Α),ヒト,組換え体,動物由来物フリー

腫瘍壊死因子-Α物理性質

貯蔵温度	-20°C
外見	粉
色	無色

安全性情報

WGK Germany	3
RTECS 番号	MT6435000

危険有害性情報のコード(GHS)

腫瘍壊死因子-Α 価格

製品番号	包装	価格	製品説明	購入
富士フイルム和光純薬株式会社(wako) W01BCS4031300	10μg	￥35000		購入
富士フイルム和光純薬株式会社(wako) W01BCS4031300	50μg	￥92000		購入
Sigma-Aldrich Japan T6674	10μg	￥93400	腫瘍壊死因子-α ヒト TNF-α, recombinant, expressed in E. coli, powder, suitable for cell culture	購入
Sigma-Aldrich Japan H8916	10μg	￥41300	腫瘍壊死因子-α ヒト TNF-α, recombinant, expressed in HEK 293 cells, suitable for cell culture	購入
富士フイルム和光純薬株式会社(wako) 654205-M	10μg	￥99000	TNF-α, Human, Recombinant, <i>E. coli</i>	購入

腫瘍壊死因子-Α 化学特性,用途語,生産方法

特長
≪アニマルフリーサイトカイン≫　本品は発現細胞の培養過程、精製過程において動物由来原料を使用していません。
使用上の注意
本品は微量のため内容物を視認できないことがあります。蓋を開ける前は必ず遠心して下さい。
使用上の注意
本品は微量のため視認できない場合があります。　チューブの蓋を開封する前には必ず遠心して下さい。
説明
Tasonermin was launched in Germany for the treatment of soft tissue sarcoma of the limbs. Recent literature is scarce for this compound. It is the first tumor necrosis factor (TNF) launched for cancer treatment to date and works through destruction of tumor blood vessels. This recombinant protein is expressed in E. coil and purified. Tasonermin is too toxic for systemic use and consequently is being used in isolated limb perfusion (ILP) for sarcoma and malignant melanoma. The product has shown notable efficacy when used in combination with melphalan to prevent amputation. In four European clinical trials involving 260 patients destined for amputation or mutilating surgery, Beromun enabled durable limb salvage in 80% of the patients. Due to the complexity of ILP, the application of tasonermin is restricted to clinical centers with sufficient experience and facilities including radionucleide-based continuous monitoring of leakage from the isolated circuit during ILP and postoperative intensive care surveillance.
使用
Tumor Necrosis Factor-a human has been used:
- as a permeability inducing agent for endothelial cell monolayer permeability assay
- as a reactive oxygen species inducer in primary rat cardiac microvascular endothelial cells (RCMVECs)
- in the activation of nuclear factor kappa B (NF-κB) in human embryonic kidney cells (HEK293), neuroblastoma SH-SY5Y cells and HeLa cells
- in the stimulation of the human keratinocyte cell line(HaCaT) and human coronary artery endothelial cells (HCAECs)
一般的な説明
The TNFα (tumor necrosis factor α) gene is mapped to human chromosome 6p21.33. TNFα is a member of TNF superfamily. TNF-α has a palmitoyl group in the cysteine residue and is phosphorylated in the transmembrane region serine residue.

腫瘍壊死因子-Α 生産企業

94948-59-1, 腫瘍壊死因子-Α キーワード

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