OLOMOUCINE II

OLOMOUCINE II 化学特性,用途語,生産方法

• 一般的な説明

  A cell-permeable 2,6,9-trisubstituted purine analog that acts as a potent, reversible, and ATP-competitive inhibitor of Cdk1/B with an IC₅₀ of 20 nM and displays increased potency over purvalanol A (Cat. No. 540500; IC₅₀ = 50 nM), Roscovitine (Cat. No. 557360; IC₅₀ = 450 nM), Bohemine (Cat. No. 203600; IC₅₀ = 1.1 μM) and Olomoucine (Cat. No. 495620; IC₅₀ = 7.0 μM). Further, exerts greater in vitro cytotoxicity in various cancer cell lines (IC₅₀ = 3.0 μM, 5.3 μM, 6.3 μM, 6.3 μM and 11.1 μM for CEM, MCF7, HOS, G631 and K562, respectively).

• Biochem/physiol Actions

  Cell permeable: yes

OLOMOUCINE II 生産企業

Global(11)Suppliers

500735-47-7, OLOMOUCINE II キーワード