ポドフィリン

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Danger

• 危険有害性情報

  H314：重篤な皮膚の薬傷?眼の損傷

  H360：生殖能または胎児への悪影響のおそれ

• 注意書き

  P202：全ての安全注意を読み理解するまで取り扱わないこ と。

  P260：粉じん/煙/ガス/ミスト/蒸気/スプレーを吸入しないこ と。

  P280：保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。

  P303+P361+P353：皮膚（または髪）に付着した場合：直ちに汚染された衣 類をすべて脱ぐこと/取り除くこと。皮膚を流水/シャワー で洗うこと。

  P305+P351+P338：眼に入った場合：水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。

ポドフィリン 価格

ポドフィリン 化学特性,用途語,生産方法

• 化学的特性

  light yellow to brown powder

• 使用

  antiallergic

• 適応症

  Podophyllin in a 10% to 25% suspension in a tincture of benzoin or alcohol can be used with success. Since this compound contains two mutagens, quercetin and kaempherol, it should used with caution in the physician’s office. It should stay on for 1 to 4 hours and be applied every week for 4 to 6 weeks. Podofilox (0.05 mL of 5%) is safer than podophyllin and should be self-applied twice a day for 3 days followed by 4 rest days to complete a treatment cycle. Topical 0.5% podophyllotoxin cream has been used b.i.d. for 3 consecutive days for a maximum of 4 weeks with clearance in 54% of patients. Podophyllum resin (podophyllin), or podofilox, a cytotoxic agent that arrests mitosis in metaphase, is used primarily for treatment of condyloma acuminata but may also be used on all other types of warts. Although now rarely available, a 25% preparation of podophyllum in compound tincture of benzoin should be applied overnight when treating common nongenital warts. A more commonly available preparation, podofilox 0.5% gel (Condylox), should be applied twice a day for 3 days, then discontinued for 4 consecutive days. The same cycle is continued until eradication of the lesions. The effectiveness as well as the irritant potential of this medication may be increased by covering with adhesive tape or plastic tape (Blenderm).

• 世界保健機関（WHO）

  Podophyllum resin, which is extracted from Indian podophyllum, is highly irritant to the skin and mucous membranes and its use in purgatives is now obsolescent. However, topical preparations remain available for the treatment of venereal and other warts and the drug is included in the WHO Model List of Essential Drugs for this purpose. Podophyllin extracts have been demonstrated to have a teratogenic potential which has led to their withdrawal in some countries and restriction of use in others. They are best avoided during pregnancy. (Reference: (WHTAC1) The Use of Essential Drugs, 2nd Report of the WHO Expert Committee, 722, , 1985)

• 一般的な説明

  Podophyllin is an alcoholic plant extract, obtained from the dried rhizome and roots of?Podoplryllui emodi. It is a powder with colors varying from light brown to greenish-yellow and exposure to heat or light turns it darker.

• 作用機序

  Podophyllum resin (podophyllin) is a chemically complex extract obtained from the roots of either of the two plants: Podophyllum peltatum (American) or Podophyllum emodi (Indian) (also called Mandrake or May-apple). Podofilox is the most cytotoxic ingredient in podophyllum resin (present in concentrations of 15% to 20% in P. peltatum and 30% to 40% in P. emodi resins) and exerts its effect by binding to intracellular microtubular proteins and thereby preventing the development of the mitotic spindle. In vitro, podophyllum also inhibits RNA synthesis. Podophyllum is used in the treatment of condyloma acuminata and other warts.

• 副作用

  Podophyllin can cause severe irritation and, if absorbed in large quantities, may produce systemic toxic effects. It is inadvisable to apply it in large amounts to mucous membranes, and it is unwise to use it in pregnant women because of its possible cytotoxic action on the fetus.

• 安全性プロファイル

  Poison by ingestion, subcutaneous, and intraperitoneal routes. An irritant to skin, eyes, and mucous membranes. Questionable carcinogen with experimental neoplastigenic data. An experimental teratogen. Other experimental reproductive effects. Combustible when exposed to heat or flames. When heated to decomposition it emits acrid smoke and irritating fumes.

ポドフィリン 生産企業

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