nimotuzumab
化学名:nimotuzumab
CAS番号.828933-51-3
英語名:nimotuzumab
CBNumberCB42498825
MW0
MOL FileMol file
nimotuzumab 化学特性,用途語,生産方法
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説明
Overexpression of epidermal growth factor receptor (EGFR), a transmembrane receptor tyrosine kinase, is prevalent in malignant tumors of epithelial origin and is especially common in breast, head and neck, colon, and lung cancer. With EGFR overexpression, prognosis is poor due to associated tumor invasion, metastasis, enhanced angiogenesis, and resistance to chemotherapy; thus, modulation of EGFR-mediated signaling is an attractive target for intervention. Small-molecule kinase inhibitors (gefitinib and erlotinib) and a monoclonal antibody (cetuximab) specific for EGFR are in clinical evaluation, but treatment cessation due to development of severe acne-like rash is common with these EGFR antagonists. Notably, nimotuzumab, a humanized form of the murine IgG2a monoclonal antibody that has been launched in India for treatment of head and neck cancers overexpressing EGFR, demonstrates clinical efficacy devoid of the rash toxicity. . -
Originator
Center for Molecular Immunology (Cuba) -
brand name
BioMab EFGR, Theraloc
nimotuzumab 生産企業
Global(15)Suppliers
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Hubei Kele Fine Chemical Co., Ltd
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