2-メチルベンゼン-1,4-ジアミン

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Warning

• 危険有害性情報

  H302：飲み込むと有害

  H315：皮膚刺激

  H319：強い眼刺激

  H335：呼吸器への刺激のおそれ

• 注意書き

  P261：粉じん/煙/ガス/ミスト/蒸気/スプレーの吸入を避ける こと。

  P280：保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。

  P301+P312：飲み込んだ場合：気分が悪い時は医師に連絡する こと。

  P302+P352：皮膚に付着した場合：多量の水と石鹸で洗うこと。

  P305+P351+P338：眼に入った場合：水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。

2-メチルベンゼン-1,4-ジアミン 価格

MSDS Information

• 2-Methyl-1,4-benzenediamine

2-メチルベンゼン-1,4-ジアミン 化学特性,用途語,生産方法

• 外観

  白色～褐色粉末～結晶

• 説明

  p-Toluylenediamine is a hair dye associated with contact dermatitis in hairdressers. Cross reactivity is observed with PPD.

• 化学的特性

  Colorless plates. Soluble in water, ethanol, ether, and hot benzene 2,5-Toluenediamine is used in hair and fur dyes.

• 使用

  2,5-Toluenediamine is used primarily in hair dye formulations as one of the major oxidation dye precursors. It is also used in the synthesis of saframine, a family of dyes used as biological stain, and may be present in indelible ink, antifreeze, and nail polish.
  As may be expected from its use in hair dye formulations, hairdressers and barbers may be exposed to 2,5-TDA. Workers in the dye manufacturing industry may also be exposed.

• 定義

  ChEBI: A diamine in which the two amino groups are substituted into toluene at the 2- and 5-positions.

• 接触アレルゲン

  Toluene-2,5-diamine is a permanent hair dye involved in contact dermatitis in hairdressers and consumers. It does not cross-react with PPD, but cosensitization is frequent.

• 安全性プロファイル

  Poison by ingestion and subcutaneous routes. A skin irritant. Mutation data reported. Questionable carcinogen. Has a toxic action upon the liver and can cause fatty degeneration of that organ. Its total effect upon the body seems to take place three chfferent ways. It is toxic to the central nervous system, producing jaundice by action on the liver and spleen, and anemia by destruction of the red blood cells. This action is quite similar to that of aniline, although by no means identical with it. Its high boiling point and the fact that the material is solid at room temperature make it somewhat less hazardous than aniline, particularly at ordinary working temperatures. The literature contains a reference to a permanent injury to an eye due to the use of this material as an eyelash dye. It is considered to be an irritating dye material. When heated to decomposition it emits toxic fumes of NOx. See also other toluene diamine entries and AROMATIC AMINES.

• 発がん性

  The possible carcinogenicity of 2,5-TDA (as sulfate salt [6369-59-1]) was tested by the National Cancer Institute in a dietary feeding study. Groups of 50 male and female F344 rats (600 or 2000 ppm) and B6C3F1 mice (600 or 1000 ppm) were given diets containing 2,5-TDA for 78 weeks and then observed for an additional period of 28–31 weeks for rats and 16–19 weeks for mice. The only statistically significant increased incidence was in lung tumors in high-dose female mice, but the evidence was not convincing enough to be attributed to 2,5-TDA. Overall, the compound was considered noncarcinogenic.

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