The rationale for the use of antacids in peptic ulcer disease
lies in the assumption that buffering of H2 in the
stomach permits healing. The use of both low and high
doses of antacids is effective in healing peptic ulcers as
compared with placebo. Healing rates are comparable
with those observed after the use of histamine (H2)
blocking agents. The buffering agents in the various
antacid preparations consist of combinations of ingredients
that include sodium bicarbonate, calcium carbonate,
magnesium hydroxide, and aluminum hydroxide.
