モノクローナル抗コラーゲン, X型抗体 マウス宿主抗体

モノクローナル抗コラーゲン, X型抗体 マウス宿主抗体 化学特性,用途語,生産方法

• 使用

  Monoclonal Anti-Collagen, Type X antibody produced in mouse has been used in
  
  • enzyme linked immunosorbent assay (ELISA)
  • dot-blot
  • immunoblotting and
  • immunohistochemistry
  
  

• 一般的な説明

  Monoclonal Anti-Collagen, Type X (mouse IgM isotype) is derived from the COL-10 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from a BALB/c mouse immunized with porcine collagen type X. Collagen type X shares a similar domain structure with type VIII collagen: a central triple-helical (COL1) domain of 50 kDa is flanked by N-terminal (NC2) and C-terminal (NC1) non-triple-helical domains.

• Biochem/physiol Actions

  Type X collagen is a product of hypertrophic chondrocytes. Type X collagen is non-fibrillar, but forms fine pericellular filaments in association with cartilage collagen. It interacts with matrix proteins, such as connexin V, chondrocalcein, collagen II and proteoglycans, as well as with Ca2+. It acts as a scaffold to avoid local collapse during endochondral ossification and also has a role in cartilage mineralization. Mutations in the NC1-encoding domain of the human α1(X) collagen gene, are associated with Schmid metaphysical chondroplasia.

モノクローナル抗コラーゲン, X型抗体 マウス宿主抗体 生産企業

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