2-ピペリドン

化学名:2-ピペリドン

CAS番号.675-20-7

英語名:2-Piperidone

CBNumberCB3680771

MFC5H9NO

MW99.13

别名

2-ピペリドン

5-アミノ吉草酸ラクタム

2-ピペリジノン

2-ピペリドン物理性質

融点	38-40 °C (lit.)
沸点	256 °C (lit.) 81-82 °C/0.1 mmHg (lit.)
比重(密度)	1.073
屈折率	1.4431 (estimate)
闪点	>230 °F
貯蔵温度	Sealed in dry,Room Temperature
溶解性	クロロホルム（微量）、メタノール（微量）
外見	低融点結晶質量
色	白→黄→茶色
PH	4.8 (200g/l, H2O, 20℃)
爆発限界(explosive limit)	1.5-8.7%(V)
水溶解度	291g/L（25℃）
Sensitive	Hygroscopic
BRN	106434
安定性：	Stable under recommended storage conditions., Stable Under Recommended Storage C
InChI	1S/C5H9NO/c7-5-3-1-2-4-6-5/h1-4H2,(H,6,7)
InChIKey	XUWHAWMETYGRKB-UHFFFAOYSA-N
SMILES	O=C1CCCCN1
CAS データベース	675-20-7(CAS DataBase Reference)
NISTの化学物質情報	2-Piperidinone(675-20-7)
EPAの化学物質情報	2-Piperidone (675-20-7)

安全性情報

危険有害性情報のコード(GHS)

外観
白色/無色～うすい黄赤色～黄色粉末～塊～透明液体
溶解性
水, エタノール, エーテル, 希無機酸に可溶。濃アルカリ水溶液に不溶。
用途
有機合成用原料。
化学的特性
white to yellowish low melting crystalline mass
使用
δ-Valerolactam is a useful synthetic intermediate. It is an intermediate used to synthesize Cenicriviroc (C256550), an experimental drug candidate for the treatment of HIV infection. It is also a starting material for a new route to hexahydrojulolidines, using intramolecular 1,4-cycloaddition.
定義
ChEBI: 2-Piperidone is a delta-lactam that is piperidine which is substituted by an oxo group at position 2. It has a role as an EC 1.2.1.88 (L-glutamate gamma-semialdehyde dehydrogenase) inhibitor. It is a member of piperidones and a delta-lactam.
製造方法
2-Piperidone can be obtained from cyclopentanone as raw material by a two-step reaction.
純化方法
Purify it by repeated fractional distillation.[Cowley J Org Chem 23 1330 1958, Reppe et al. Justus Liebigs Ann Chem 596 198 1955, IR: Huisgen et al. Chem Ber 90 1437 1957.] The hydrochloride has m 183-184o (from isoPrOH or EtOH/Et2O) [Hurd et al. J Org Chem 17 865 1952], and the oxime has m 122.5o (from pet ether) [Behringer & Meier Justus Liebigs Ann Chem 607 67 1957]. The picrate has m 92-93o. [Beilstein 21 H 239, 21 III/IV 3170, 21/6 V 396.]

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