Methyl (4-bromobenzoyl)-L-cysteinate

Methyl (4-bromobenzoyl)-L-cysteinate 化学特性,用途語,生産方法

• 使用

  Methyl (4-bromobenzoyl)-L-cysteinate is a chemoselective thiol probe for detection of electrophilic metabolites. As it is often difficult to isolate low-abundance natural products from extracts, metabolities with bioactivity or therapeutic potential may be missed. Castro-Falcón, et al developed a reactivity-guided approach using thiolate probes to discover electrophilic natural products - a cysteine-based probe and thiophenol-based probe. Both consist of
  
  • A chemoselective reagent for covalent reactivity with a pharmacophore,
  • A conspicuous UV/VIS or mass spectrometric (MS) tag,
  • A linker between the tag and reagent. Methyl (4-bromobenzoyl)-L-cysteinate contains a bromine MS tag and phenyl bromide UV tag that was demonstrated to chemoselectively label enone-, β-lactam-, and β-lactone-based natural products.
  
  Complementarily, a thiophenol probe (cat# 125237) with a chlorine MS tag and phenyl chloride UV tag labeled epoxide-based natural products. These probes can be used in diverse extracts (bacterial, fungal, plant) to chemically faciliate access to high-value metabolites.

Methyl (4-bromobenzoyl)-L-cysteinate 生産企業

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Methyl (4-bromobenzoyl)-L-cysteinate スペクトルデータ(¹HNMR)