チオチキセン

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Warning

• 危険有害性情報

  H302：飲み込むと有害

  H351：発がんのおそれの疑い

• 注意書き

  P201：使用前に取扱説明書を入手すること。

  P202：全ての安全注意を読み理解するまで取り扱わないこ と。

  P264：取扱い後は皮膚をよく洗うこと。

  P264：取扱い後は手や顔をよく洗うこと。

  P270：この製品を使用する時に、飲食または喫煙をしないこ と。

  P281：指定された個人用保護具を使用すること。

  P301+P312：飲み込んだ場合：気分が悪い時は医師に連絡する こと。

  P308+P313：暴露または暴露の懸念がある場合：医師の診断/手当てを 受けること。

  P330：口をすすぐこと。

  P405：施錠して保管すること。

  P501：内容物/容器を．．．に廃棄すること。

チオチキセン 化学特性,用途語,生産方法

• 効能

  統合失調症治療薬, ドパミン受容体拮抗薬

• 説明

  In 2002, the American Association of Poison Control Centers’ Toxic Exposure Surveillance System reported 5224 human exposures to phenothiazines, thioxanthenes, and other neuroleptic medications; 3691 were in adults and 808 in children. Unintentional and intentional exposures accounted for 43.7 and 47.8%, respectively. There were 417 (8.0%) adverse drug reactions reported. Thioxanthenes are chemical compounds in which the oxygen atom in xanthene is replaced with a sulfur atom. They are also related to phenothiazines. Several derivatives are used as typical antipsychotics in the treatment of schizophrenia and other psychoses. The thioxanthenes, as a class, are closely related chemically to the phenothiazines. The major structural difference is that the nitrogen at position 10 in the phenothiazines is replaced by a carbon atom with a double bond to the side chain, as shown in the chemical structure of flupenthixol, which has a double-bonded carbon in the number 10 position. Clopenthixol is a typical antipsychotic drug of the thioxanthenes class and a racemic mixture of cis and trans isomers. Zuclopenthixol, the pure cis isomer, has been much more widely used. Both drugs are equally effective as antipsychotics and have similar adverse effect profiles, but clopenthixol is half as active on a milligram-to-milligram basis and appears to produce more sedation in comparison.

• 使用

  Thioxanthenes are used as neuroleptic agents, antipsychotics, and major tranquilizers in the treatment of psychosis, including schizophrenia, senile psychosis, pathological jealousy, and borderline personality disorder. Other uses include the treatment of pain, postoperative neuralgia, sedation, anxiety neurosis, childhood behavior problems, and depression. The maximum therapeutic daily oral dose for chlorprothixene, flupenthixol, and thiothixene is 600, 224, and 60 mg, respectively; the maximum intramuscular doses are 200 mg day^-1, 100 mg weekly, and 30 mg day^-1, respectively. Some thioxanthenes and thioxanthenones have shown signs of possible human therapeutic potential against tumors in mice and in vitro assays, and some thioxanthenes have been shown to have cytotoxic and antimicrobial activities.
  Chlorprothixene is primarily indicated in conditions such as agitation, mania, psychosis, schizophrenia, and can also be given in adjunctive therapy as an alternative drug of choice for anxiety and herpetic neuralgia. Flupenthixol (HCl and decanoate) is primarily indicated in conditions such as depression, muscle spasms of varied etiology, pain, personality disorder, postoperative nausea and vomiting, psychosis, relief of discomfort in mild urinary tract infections, and schizophrenia. Flupenthixol is also seen to possess powerful antibacterial activity both in vitro and in vivo in mouse experiments. It is bacteriostatic in vitro both against gram-positive and gram-negative bacteria. Thiothixene is used in the management of schizophrenia. It has not been evaluated in the management of behavioral complications in patients with mental retardation.
  Zuclopenthixol is primarily indicated in conditions such as dementia, to enhance permeation of subcutaneous or intramuscular injections, labyrinthine disorders, prolactinoma, psychosis, schizophrenia, and second trimester abortion. It is also used in the treatment of acute bipolar mania.

• 環境運命予測

  Long-range transport: handling of thioxanthenes should only be performed by personnel trained and familiar with handling potent active pharmaceutical ingredients. In case of handling, avoid inhalation and contact with skin, eyes, and clothing, as these materials may be an irritant. These substances are considered nonhazardous for transport.

チオチキセン 生産企業

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