dl-ザルトプロフェン

dl-ザルトプロフェン 化学特性,用途語,生産方法

• 説明

  Zaltoprofen is a potent non-steroidal antiinflammatory drug (NSAID) with analgesic activity. In rats and mice, zaltoprofen is reported to be equipotent or superior to other NSAlDs in bradykinin-induced pain, acetic acid-induced writhing, carrageenan-induced hyperalgesia, and in several other experimental models of analgesia. It acts by selectively suppressing the production of prostaglandins at the inflammatory site and not in other organs such as stomach and kidney, therefore, has remarkably low gastric side effects that are associated with conventional antiinflammatory agents.

• 化学的特性

  Off-White to Pale Yellow Crystalline Solid

• 使用

  Anti-inflammatory activity resides in (S)-enantiomer

• 合成

  The cyclization of 5-(1- cyanoethyl)-2-(phenylthio)phenylacetic acid in presence of polyphosphoric acid at 120 ℃ gives 2-(10-oxo-10,11-dihydrodibenzo[b,f ]thiepin- 2-yl)propionitrile, which is then hydrolyzed with KOH in refluxing ethanol – water to zaltoprofen.
  

  

dl-ザルトプロフェン 上流と下流の製品情報

dl-ザルトプロフェン 生産企業

Global(115)Suppliers

89482-00-8, dl-ザルトプロフェン キーワード