5,6,7,8-テトラヒドロ-1,2,3,10,11,12-ヘキサメトキシ-6,7-ジメチルジベンゾ[a,c]シクロオクテン-6-オール

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Warning

• 危険有害性情報

  H302：飲み込むと有害

  H400：水生生物に強い毒性

• 注意書き

  P273：環境への放出を避けること。

5,6,7,8-テトラヒドロ-1,2,3,10,11,12-ヘキサメトキシ-6,7-ジメチルジベンゾ[a,c]シクロオクテン-6-オール 価格

5,6,7,8-テトラヒドロ-1,2,3,10,11,12-ヘキサメトキシ-6,7-ジメチルジベンゾ[a,c]シクロオクテン-6-オール 化学特性,用途語,生産方法

• 外観

  白色の結晶又は結晶性の粉末

• 溶解性

  メタノール又はジエチルエーテルに溶けやすく、水にほとんど溶けない。

• 説明

  Schizandrin is a dibenzocyclooctadiene lignan and a major component of S. chinensis and has diverse biological activities. It induces cell cycle arrest at the G₀/G₁ phase and inhibits growth of T47D and MDA-MB-231 breast cancer cells when used at a concentration of 100 μM. Schizandrin (10 and 100 μM) prevents glutamate-induced cytotoxicity, inhibits production of nitric oxide (NO) and reactive oxygen species (ROS), and preserves the mitochondrial membrane potential in isolated rat cortical cells. It reduces apoptosis induced by cisplatin in HK-2 human kidney cells. In vivo, schizandrin (1 and 10 mg/kg, p.o.) reverses scopolamine-induced impairment of spatial memory and the passive avoidance response in rats. It enhances oxotremorine-induced tremors in mice. Schizandrin (10 mg/kg) reduces serum levels of IgE, IgG1, IL-4, and IFN-γ in an ovalbumin-sensitized mouse model of allergy.

• 使用

  Schizandrin may be used in oxidative stress-related cell signaling studies.

• 主な応用

  Schizandrin is a natural compound that belongs to the group of schisandrins. Schizandrins are a class of compounds with biochemical properties and biological activities, such as anti-inflammatory, antioxidant, and anti-cancer effects. This compound has been shown to have pro-apoptotic properties in a model system. It has also demonstrated the ability to inhibit influenza A virus replication in vitro and protect mice against Listeria monocytogenes infection. It can be used as an inhibitor of gsh-px activity in myocardial infarcts.

• Biochem/physiol Actions

  Schizandrin is a natural product with several biological properties involved with antioxidant and anti-inflammatory activities. It reduces the formation of ROS, inhibits the mitochondrial pathway of the apoptotic process and oxidative stress. Schizandrin has been reported to have hepatoprotective, antitumor, antiviral, and antiamnesic effects, and has neuroprotective activity against glutamate induced neurotoxicity.

5,6,7,8-テトラヒドロ-1,2,3,10,11,12-ヘキサメトキシ-6,7-ジメチルジベンゾ[a,c]シクロオクテン-6-オール 生産企業

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5,6,7,8-テトラヒドロ-1,2,3,10,11,12-ヘキサメトキシ-6,7-ジメチルジベンゾ[a,c]シクロオクテン-6-オール スペクトルデータ(¹HNMR)

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