2-[2-[[4-(ジフェニルメチル)ピペラジノ]カルボニルメトキシ]アセチルアミノ]-5-クロロ安息香酸ナトリウム

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Warning

• 危険有害性情報

  H302：飲み込むと有害

  H400：水生生物に強い毒性

• 注意書き

  P273：環境への放出を避けること。

2-[2-[[4-(ジフェニルメチル)ピペラジノ]カルボニルメトキシ]アセチルアミノ]-5-クロロ安息香酸ナトリウム 価格

2-[2-[[4-(ジフェニルメチル)ピペラジノ]カルボニルメトキシ]アセチルアミノ]-5-クロロ安息香酸ナトリウム 化学特性,用途語,生産方法

• 説明

  TM5275 is an inhibitor of plasminogen activator inhibitor 1 (PAI-1; IC₅₀ = 6.95 μM), a serine-protease inhibitor involved in thrombosis. TM5275 inhibits formation of a complex consisting of tissue plasminogen activator (tPA), PAI-1, and GFP on vascular endothelial cells (VECs) in vitro, prolonging the time that tPA is retained on VECs. It also enhances fibrin clot dissolution and plasminogen accumulation in vitro and has antithrombotic effects in rat models of thrombosis. TM5275 (10 and 50 mg/kg) decreases blood clot weight in an arteriovenous shunt thrombosis model and increases the time to primary occlusion in a ferric chloride-treated carotid artery thrombosis model when used at doses of 1 and 3 mg/kg. In a cynomolgus monkey model of photochemical-induced arterial thrombosis, TM5275 (10 mg/kg) increases the time to primary occlusion. It does not affect platelet activity, activated partial thromboplastin time, prothrombin time, or prolong bleeding time.

• 使用

  TM 5275 Sodium Salt is a novel inhibitor of plasminogen activator inhibitor-1 (PAI-1), which provides antithrombitic benefits devoid of bleeding in primates.

• Biochem/physiol Actions

  TMS5275 is an orally available, potent and selective inhibitor of PAI-1 that delivers antithrombotic benefits devoid of bleeding effect in nonhuman primates.

2-[2-[[4-(ジフェニルメチル)ピペラジノ]カルボニルメトキシ]アセチルアミノ]-5-クロロ安息香酸ナトリウム 生産企業

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