1-Boc-4-(4-fluoro-phenylamino)-piperidine

1-Boc-4-(4-fluoro-phenylamino)-piperidine 化学特性,用途語,生産方法

• 製造方法

  Sodium cyanoborohydride (661 mg, 10.0 mmol) was added to a methylene chloride solution (30 ml) of t-butyl 4-oxopiperidine-1-carboxylate (2.66 g, 13.1 mmol), 4-fluoroaniline (1.46 g, 13.1 mmol) and acetic acid (0.750 ml, 13.1 mmol), at 0°C, and stirring was carried out at room temperature for 15 hours. A saturated aqueous sodium hydrogencarbonate solution was added to the reaction solution, followed by extraction with ethyl acetate, and the extract was washed sequentially with water and saline, and dried over anhydrous sodium sulfate. The organic layer was concentrated and the resulting residue was washed with diisopropyl ether, followed by drying to afford 1-Boc-4-(4-Fluoro-Phenylamino)-Piperidine. Yield 80%.
  

1-Boc-4-(4-fluoro-phenylamino)-piperidine 上流と下流の製品情報

288573-56-8, 1-Boc-4-(4-fluoro-phenylamino)-piperidine キーワード