BD1047二臭化水素酸塩

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Danger

• 危険有害性情報

  H315：皮膚刺激

  H318：重篤な眼の損傷

  H335：呼吸器への刺激のおそれ

• 注意書き

  P280：保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。

  P302+P352：皮膚に付着した場合：多量の水と石鹸で洗うこと。

BD1047二臭化水素酸塩 価格

BD1047二臭化水素酸塩 化学特性,用途語,生産方法

• 説明

  BD 1047 is a selective antagonist of sigma-1 (σ₁) receptors (K_i = 0.9 nM in a radioligand binding assay). It is selective for σ₁ receptors with binding affinity values greater than 10,000 nM for human recombinant dopamine, opioid, PCP, and serotonin receptors in vitro. In vivo, pretreatment with BD 1047 protects against convulsions and lethality induced by cocaine (Item Nos. 16186 | ISO60176) and reduces cocaine-induced locomotor activity. It reduces dystonias induced by the σ receptor agonists haloperidol and di-o-tolylguanidine (DTG) in rats in a dose-dependent manner. In vivo administration of BD 1047 also attenuates mechanical allodynia and microglial activation in a rat model of bone cancer pain.

BD1047二臭化水素酸塩 生産企業

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BD1047二臭化水素酸塩 スペクトルデータ(¹HNMR)

138356-21-5, BD1047二臭化水素酸塩 キーワード