4-(3-フェノキシベンジル)-1-ピペラジンカルボン酸4-ニトロフェニル

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Warning

• 危険有害性情報

  H400：水生生物に強い毒性

• 注意書き

  P273：環境への放出を避けること。

4-(3-フェノキシベンジル)-1-ピペラジンカルボン酸4-ニトロフェニル 価格

4-(3-フェノキシベンジル)-1-ピペラジンカルボン酸4-ニトロフェニル 化学特性,用途語,生産方法

• 説明

  Fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL) mediate the hydrolysis of the endocannabinoids arachidonoyl ethanolamide (AEA) and 2-arachidonoylglycerol (2-AG), respectively. JZL 195 is a potent inhibitor of both FAAH and MAGL (IC₅₀s = 2 and 4 nM, respectively). It poorly inhibits neuropathy target esterase and ABHD6 and does not inhibit other brain serine hydrolases. JZL 195 displays time-dependent inhibition of FAAH and MAGL in vivo, consistent with a covalent mechanism of activation. The in vivo inhibitory actions of JZL 195 against FAAH and MAGL are comparable to those of the selective inhibitors PF-3845 and JZL 184 , respectively. Through its inhibitory actions, JZL 195 simultaneously augments brain levels of AEA and 2-AG, producing antinociceptive, cataleptic, and hypomotility effects like those produced by direct CB₁ agonists.

• 使用

  JZL195 is a selective and efficacious dual FAAH/MAGL inhibitor with IC50 of 13 nM and 19 nM for mouse brain FAAH and MAGL respectively.

4-(3-フェノキシベンジル)-1-ピペラジンカルボン酸4-ニトロフェニル 生産企業

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