TRIMIDOX

TRIMIDOX 化学特性,用途語,生産方法

• 説明

  Ribonucleotide reductase, the rate-limiting enzyme for de novo DNA synthesis, is a common target for chemotherapy. Its increased activity in cancer cells is associated with malignant transformation and proliferation. Trimidox is a specific ribonucleotide reductase inhibitor that reduces levels of dGTP and dCTP in HL-60 cells, inducing apoptosis via activation of caspases without altering the cell cycle distribution. Trimidox inhibits growth of human promyelocytic leukemia HL-60 cells with an IC₅₀ value of 35 μM.

• 使用

  Trimidox is a specific ribonucleotide reductase inhibitor.

TRIMIDOX 生産企業

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