(15S)-20,21-(エポキシエタノ)-15-ヒドロキシ-4-メチル-16-メチレンベアトカン

(15S)-20,21-(エポキシエタノ)-15-ヒドロキシ-4-メチル-16-メチレンベアトカン 化学特性,用途語,生産方法

• 説明

  This alkaloid occurs in Garrya species and is a major constituent of G. veatchii. It is laevorotatory with [α]^27.5_D - 69.01°. The crystalline hydrochloride has m.p. 2Sl-2°C (dec.); hydrobromide, m.p. 229-2300 C and the hydriodide, m.p. 222-3°C (dec.). The O-acetate has m.p. l52-3°C and yields a hydrochloride, m.p. 258-9°C. The structure has been determined by chemical analysis and from spectroscopic data.

• 参考文献

  Wiesneretal., Can. J. Chem., 30,608 (1952)
  Wiesner et al., Ber., 86,800 (1953)
  Wiesner, Edwards., Experientia, 11,255 (1955)
  Vorbrueggen, Djerassi., J. Amer. Chem. Soc., 84, 2999 (1962)
  Nagata et al., ibid, 86,929 (1964)
  Synthesis: Valenta, Wiesner, Wong., Tetrahedron Lett., 2437 (1964)
  Fujita, Fujita, Katayama., Tetrahedron, 26, 1009 (1970)
  Wiesner et al., Experientia, 26, 471 (1970)