(6aS)-5,6a,7,8,9,11-ヘキサヒドロ-6β,11β-メタノ-6H-1,3-ベンゾジオキソロ[5,6-c][1]ベンゾアゼピン-8α,9β-ジオール

(6aS)-5,6a,7,8,9,11-ヘキサヒドロ-6β,11β-メタノ-6H-1,3-ベンゾジオキソロ[5,6-c][1]ベンゾアゼピン-8α,9β-ジオール 化学特性,用途語,生産方法

• 説明

  This alkaloid occurs in Narcissus poeticus, Pancratium maritium and Rhodo_x0002_phiala bifida. It yields long, colourless prisms when recrystallized from MeOH and is laevorotatory with [α]²⁵_D - 74° (c 0.02, MeOH). The ultraviolet spectrum has two absorption maxima at 241 and 292 mil. It yields a crystalline perchlorate, m.p. 163-6°C and a picrate, m.p. 249-2S2°C. Two non-phenolic hydroxyl groups and one methylenedioxy group are present in the molecule. The 2-a-O-acetate is an amorphous solid which cannot be obtained crystalline but the 3-{3-0-acetate forms colourless crystals from MeOH, m.p. 213-6°C. The O,O-diacetate, also crystalline, has m.p. 163-S°C. The O-methyl derivatives occur naturally, the 2-methyl compound is Montanine (q.v.) and the 2:3-dimethyl ether is Manthine (q.v.). The structure is based primarily upon the mass spectrum fragmentation pattern.

• 参考文献

  Sandberg, Michel., Lloydia, 26, 78 (1963)
  Structure:
  Wildman, Brown.,J. Amer. Chem. Soc., 90,6439 (1968)

(6aS)-5,6a,7,8,9,11-ヘキサヒドロ-6β,11β-メタノ-6H-1,3-ベンゾジオキソロ[5,6-c][1]ベンゾアゼピン-8α,9β-ジオール 上流と下流の製品情報