19β-メチル-2-オキソホルモサナン-16-カルボン酸メチル

19β-メチル-2-オキソホルモサナン-16-カルボン酸メチル 化学特性,用途語,生産方法

• 説明

  A further constituent of various Uncaria species, this alkaloid is stereoisomeric with the preceding alkaloid. It crystallizes from EtOH in colourless needles or plates and has [α]_D + 91.3°. The hydrochloride forms colourless columns of the dihydrate, m.p. 227 _8°C (dec.) and the methiodide yields transparent plates, m.p. 214°C (dec.). The N-acetyl derivative has also been prepared, m.p. 165°C.

• 参考文献

  Raymond-Hamet., Compt. rend., 203, 1383 (1936)
  Kondo, Ikeda.,]. Pharm. Soc., Japan, 61,416,453,460 (1941)
  Kondo, Ikeda., ibid, 62, 15 (1942)
  Raymond-Hamet., Compt. rend., 230, 1405 (1950)
  Raymond-Hamet., ibid, 245, 1458 (1957)
  Hendrickson., J. Amer. Chern. Soc., 84, 650 (1962)
  Revised stereochemistry: Shamma et ai., J. Amer. Chern. Soc., 89, 1739 (1967)
  Beechametai., Chern. Commun., 535 (1967)