β-ヒドロキシイソ吉草酸

化学名:β-ヒドロキシイソ吉草酸

CAS番号.625-08-1

英語名:beta-Hydroxyisovaleric Acid

CBNumberCB3213104

MFC5H10O3

MW118.13

MOL File625-08-1.mol

别名

β-ヒドロキシイソ吉草酸

3-ヒドロキシ-3-メチルブタン酸

β-ヒドロキシ-β-メチル酪酸

β-ヒドロキシイソ吉草酸物理性質

融点	?80 °C (lit.)
沸点	88 °C/1 mmHg (lit.)
比重(密度)	0.938 g/mL at 25 °C (lit.)
屈折率	n20/D 1.4415(lit.)
闪点	113 °C
貯蔵温度	Keep in dark place,Sealed in dry,Room Temperature
溶解性	DMF:10.0(Max Conc. mg/mL);84.65(Max Conc. mM) DMSO:10.0(Max Conc. mg/mL);84.65(Max Conc. mM) Ethanol:10.0(Max Conc. mg/mL);84.65(Max Conc. mM) PBS (pH 7.2):10.0(Max Conc. mg/mL);84.65(Max Conc. mM)
酸解離定数(Pka)	4.38±0.10(Predicted)
外見	液体
比重	1.10
色	ペールイエロー
水溶解度	水およびエタノールに可溶。
BRN	1743952
InChIKey	AXFYFNCPONWUHW-UHFFFAOYSA-N
CAS データベース	625-08-1(CAS DataBase Reference)

安全性情報

主な危険性	Xi
Rフレーズ	36/37/38
Sフレーズ	26-36
RIDADR	UN 3334
WGK Germany	3
F	10-13-21
HSコード	29181990
消防法	危-4-3-III
化審法	(2)-1429

危険有害性情報のコード(GHS)

β-ヒドロキシイソ吉草酸価格

製品番号	包装	価格	製品説明	購入
富士フイルム和光純薬株式会社(wako) W01ALF042722	10g	￥18200	3-ヒドロキシ-3-メチル酪酸, 96%	購入
富士フイルム和光純薬株式会社(wako) W01ALF042722	50g	￥47500	3-ヒドロキシ-3-メチル酪酸, 96%	購入
東京化成工業 H0701	5g	￥4300	β-ヒドロキシイソ吉草酸 >96.0%(GC)(T)	購入
東京化成工業 H0701	25g	￥14900	β-ヒドロキシイソ吉草酸 >96.0%(GC)(T)	購入
Sigma-Aldrich Japan 55453	1g	￥49600	β-ヒドロキシイソ吉草酸 ≥95.0% (T)	購入

β-ヒドロキシイソ吉草酸化学特性,用途語,生産方法

外観
無色～うすい黄色、液体
用途
有機合成原料。
説明
β-Hydroxy β-methylbutyric acid (HMB), or β-hydroxy β- methylbutyrate, is a metabolite of the essential amino acid leucine and is synthesized in the human body. It plays a part in protein synthesis and was discovered by Dr. Steven L. Nissen at Iowa State University. It has been used in scientific studies to purportedly increase muscle mass and decrease muscle breakdown. Nissen held the original patent on the metabolite as a nutritional supplement. It was discovered in pigs, and small quantities can also be found in grapefruit, alfalfa, and catfish. As a supplement it is usually sold as a calcium salt.
Research published in the Journal of Applied Physiology has shown that HMB may have an effect on increasing muscle weight and strength. A review in Nutrition & Metabolism provides an in depth and objective analysis of HMB research. The same study lists as HMB' s proposed mechanisms of action the following:
Increased sarcolemmal integrity via conversion to HMG-CoA
Enhanced protein synthesis via the mTOR pathway
Depression of protein degradation through inhibition of the ubiquitin pathway
Three grams of Calcium beta-hydroxy-beta-methylbutyrate per day may help muscles combat protein breakdown, assist in muscle repair and support increased endurance. Studies suggest its benefits may be greater for the untrained. Also, well-controlled scientific studies have found increases in muscle mass and decreases in body fat in 70 year old men. It has helped patients with chronic obstructive pulmonary disease in hospital intensive care units, muscle wasting associated with HIV or AIDS and with cancer, and trauma victims with severe injuries.
The human body produces about 0.2 - 0.4 grams per day. Standard doses in research studies have been 1.5 to 3.0 grams per day, usually divided into two doses.
化学的特性
colorless to light yellow liquid
使用
β-Hydroxyisovaleric Acid is a metabolite of the essential amino acid Leucine and is synthesized in the human body. Studies suggest that β-Hydroxyisovaleric Acid may have an effect on increasing muscle weight and strength. The presence of elevated β-Hydroxyisovaleric Acid is a sensitive marker of biotin deficiency and may indicate the presence of a genetic disorder such as biotinidase deficiency or holocarboxylase synthetase deficiency.
定義
ChEBI: A 3-hydroxy monocarboxylic acid that is isovaleric acid substituted at position 3 by a hydroxy group. Used as indicator of biotin deficiency.

β-ヒドロキシイソ吉草酸上流と下流の製品情報

β-ヒドロキシイソ吉草酸生産企業

625-08-1, β-ヒドロキシイソ吉草酸キーワード

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β-ヒドロキシイソ吉草酸

危険有害性情報のコード(GHS)

β-ヒドロキシイソ吉草酸 価格

β-ヒドロキシイソ吉草酸 化学特性,用途語,生産方法

β-ヒドロキシイソ吉草酸 上流と下流の製品情報

β-ヒドロキシイソ吉草酸 生産企業

625-08-1, β-ヒドロキシイソ吉草酸 キーワード

β-ヒドロキシイソ吉草酸価格

β-ヒドロキシイソ吉草酸化学特性,用途語,生産方法

β-ヒドロキシイソ吉草酸上流と下流の製品情報

β-ヒドロキシイソ吉草酸生産企業

625-08-1, β-ヒドロキシイソ吉草酸キーワード