L-744,832

L-744,832 価格

L-744,832 化学特性,用途語,生産方法

• 化学的特性

  L-744,832 is White Cyrstalline Solid

• 使用

  L-744,832 is ras farnesyltransferase inhibitor. Induces tumor regression in transgenic mice with multiple oncogenic mutations by mediating alterations in both cell cycle control and apoptosis. Induces p21 expressoin and arrests cells at G1. Causes enhanced mitotic

• 一般的な説明

  A cell-permeable potent and selective thiol-containing peptidomimetic farnesyltransferase (FTase) inhibitor with anti-tumor properties. Rapidly blocks p70S6K activation and DNA synthesis and promotes apoptosis in transgenic mice. Induces p21 expression and cell cycle arrest in the G₁ phase. Displays synergistic effect with paclitaxel and epothilones in inhibiting tumor growth. Also mimics many of the effects of Rapamycin (Cat. No. 553210) and may be effective against tumors that exhibit inappropriate activation of the mTOR/p70S6K pathway.

L-744,832 生産企業

Global(36)Suppliers

1177806-11-9, L-744,832 キーワード