tert-Butyl (trans-3-(hydroxymethyl)cyclobutyl)carbamate

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Warning

• 危険有害性情報

  H302：飲み込むと有害

• 注意書き

  P280：保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。

  P305+P351+P338：眼に入った場合：水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。

tert-Butyl (trans-3-(hydroxymethyl)cyclobutyl)carbamate 価格

tert-Butyl (trans-3-(hydroxymethyl)cyclobutyl)carbamate 化学特性,用途語,生産方法

• 合成

  To a stirred solution of methyl (1R,3R)-3-((tert-butoxycarbonyl)amino)cyclobutane-1-carboxylate (1.0 g, 4.4 mmol) in THF (20 mL) was added 3M lithium borohydride (9 mL, 9 mmol) at 0° C. Then the reaction mixture was heated and stirred at 60° C for 3 h. The reaction mixture was then transferred into dilute NaOH and the resulting mixture was extracted using ethyl acetate (3×50 mL). The combined organic layer was dried over anhydrous sodium sulfate and filtered. The filtrate was evaporated under reduced pressure and the crude product was purified using silica gel column chromatography (3% MeOH-DCM) to give tert-Butyl (trans-3-(hydroxymethyl)cyclobutyl)carbamate as a white solid (0.8 g, 91%).
  

tert-Butyl (trans-3-(hydroxymethyl)cyclobutyl)carbamate 生産企業

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tert-Butyl (trans-3-(hydroxymethyl)cyclobutyl)carbamate スペクトルデータ(¹HNMR)

167081-37-0, tert-Butyl (trans-3-(hydroxymethyl)cyclobutyl)carbamate キーワード