5-(4-クロロフェニル)-N-(3,5-ジメトキシフェニル)-2-フランカルボキサミド

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Warning

• 危険有害性情報

  H302：飲み込むと有害

• 注意書き

  P264：取扱い後は皮膚をよく洗うこと。

  P264：取扱い後は手や顔をよく洗うこと。

  P270：この製品を使用する時に、飲食または喫煙をしないこ と。

  P330：口をすすぐこと。

5-(4-クロロフェニル)-N-(3,5-ジメトキシフェニル)-2-フランカルボキサミド 価格

5-(4-クロロフェニル)-N-(3,5-ジメトキシフェニル)-2-フランカルボキサミド 化学特性,用途語,生産方法

• 説明

  Na_v1.8 is a tetrodotoxin-resistant (TTX-R) sodium channel with high activation threshold and slow inactivating kinetics that is highly expressed in small-diameter sensory neurons and has been implicated in signaling various types of pain. A-803467 is a sodium channel blocker with high-affinity and selectivity for inhibiting human Na_v1.8 sodium channels (IC₅₀ = 8 nM when stimulated at half-maximal inactivation and IC₅₀ = 79 nM at a resting state). This compound is unusual in that it blocks hNav1.8 at negative resting membrane potentials (many small molecule sodium channel blockers show a reduced affinity for the resting state) and does not demonstrate significant frequency-dependent block during a 10 Hz pulse train. A-803467 dose-dependently reduces behavioral responses in a variety of neuropathic and inflammatory pain models.

• 化学的特性

  White Solid

• 一般的な説明

  The small molecule A-803467 is a potent and selective Nav1.8 sodium channel blocker. Nav1.8 is a tetrodotoxin-resistant (TTX-R) sodium channel that contributes to pain sensation by transmitting pain stimuli in peripheral sensory neurons; blockage of this channel by A-803467 reduces pain with varying effectiveness in a number of different models. A-803467 has been used to further understand the role of Nav1.8 in transmitting pain stimuli and also can be used as an analgesic.

• 生物活性

  Selective blocker of Na V 1.8 channels (IC 50 values are 8, 2450, 6740, 7340 and 7380 nM for hNa V 1.8, hNa V 1.3, hNa V 1.7, hNa V 1.5 and hNa V 1.2 channels respectively). Shows no significant activity against TRPV1, P2X 2/3 , Ca V 2.2 and KCNQ2/3 channels. Antinociceptive; potently attenuates mechanical allodynia in two models of neuropathic pain following i.p. administration.

5-(4-クロロフェニル)-N-(3,5-ジメトキシフェニル)-2-フランカルボキサミド 生産企業

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5-(4-クロロフェニル)-N-(3,5-ジメトキシフェニル)-2-フランカルボキサミド スペクトルデータ(¹HNMR)

944261-79-4, 5-(4-クロロフェニル)-N-(3,5-ジメトキシフェニル)-2-フランカルボキサミド キーワード